DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and KLK1

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_002248.1	Gene:	KLK1 / 3816	HGNCID:	6357	Length:	262	Species:	Homo sapiens

Alignment Length:	276	Identity:	88/276 - (31%)
Similarity:	120/276 - (43%)	Gaps:	49/276 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 RLVGGHNTGLFEFPW-TTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHT-----MGR-NLTA 188
            |:|||........|| ..|..:.|      :.||...:.::|:|||||||..     :|| ||.
Human    24 RIVGGWECEQHSQPWQAALYHFST------FQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLF- 81

  Fly   189 AILGEWNRDTDPDCENDLNGVRECAP-PHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQ 252
                        |.||....|..... ||....:..:..|.:.::.:|.:|:.||||:.|.:.:
Human    82 ------------DDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTI- 133

  Fly   253 MQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGSS--KIKQKAMLHIQPQDQCQEAFYKDT 315
            ...::.|.||.:...     .||....||||..|....|  ...|...|.|.|.|:|::|..:
Human   134 TDAVKVVELPTEEPE-----VGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQ-- 191

  Fly   316 KITLADSQMCAGG-EIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYT 379
            |:|  |..:|.|. |.|.|:|.|||||||..:.         .|.||.|.|...|||.....:..
Human   192 KVT--DFMLCVGHLEGGKDTCVGDSGGPLMCDG---------VLQGVTSWGYVPCGTPNKPSVAV 245

  Fly   380 RVSSYMDWIESTIRAN 395
            ||.||:.|||.||..|
Human   246 RVLSYVKWIEDTIAEN 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	82/267 (31%)
		Tryp_SPc	133..391	CDD:238113	84/268 (31%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	84/269 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910