DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and PRSS41

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001382429.1	Gene:	PRSS41 / 360226	HGNCID:	30715	Length:	334	Species:	Homo sapiens

Alignment Length:	303	Identity:	88/303 - (29%)
Similarity:	123/303 - (40%)	Gaps:	75/303 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 CGSAFSFRLV-GGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCI--HTMGRN 185
            ||......|| ||..:....:||...|...     :.:.||.|.:::||:|:||||.  |.....
Human    62 CGHREIHALVAGGVESARGRWPWQASLRLR-----RRHRCGGSLLSRRWVLSAAHCFQKHYYPSE 121

  Fly   186 LTAAILGE-------WN--------RDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNY 235
            .|.. |||       ||        :..|.....|..||                         .
Human   122 WTVQ-LGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGV-------------------------L 160

  Fly   236 RNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLAGSAAD--VSGWGKTESSGSSKIK---- 294
            |||||||||:..|.:  ...::|:|:......:.::     .|  |:|||....||:....
Human   161 RNDIALLRLASSVTY--NAYIQPICIESSTFNFVHR-----PDCWVTGWGLISPSGTPLPPPYNL 218

  Fly   295 QKAMLHIQPQDQCQEAFYK-DTKITLADSQMCAGGEIG-VDSCSGDSGGPLTVEANTASGNRYVY 357
            ::|.:.|....:|...|.: .::..:.||..|||.|.| ||:|.|||||||..:.     :...|
Human   219 REAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDK-----DGLWY 278

  Fly   358 LAGVVSIGRKHCGTALFSGIYTRVSSYMDWI-----ESTIRAN 395
            ..|:||.| ..||.....|:||.:|.|..||     .||.|.|
Human   279 QVGIVSWG-MDCGQPNRPGVYTNISVYFHWIRRVMSHSTPRPN 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	80/282 (28%)
		Tryp_SPc	133..391	CDD:238113	81/288 (28%)
PRSS41	NP_001382429.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910