DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and OVCH2

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_016873148.1	Gene:	OVCH2 / 341277	HGNCID:	29970	Length:	569	Species:	Homo sapiens

Alignment Length:	319	Identity:	88/319 - (27%)
Similarity:	140/319 - (43%)	Gaps:	66/319 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 RPPSGIDQLPEHPYCGSA------------FSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYAC 162
            |..|....||:.|.||.:            || |::||.......:||...|:..     :.:.|
Human    23 RGKSATLSLPKAPSCGQSLVKVQPWNYFNIFS-RILGGSQVEKGSYPWQVSLKQR-----QKHIC 81

  Fly   163 GASFIAQRWLLTAAHCIHTMGRNLTAAI---LGEWN-RDTDPDCENDLNGVRECAPPHIRVTIDR 223
            |.|.::.:|::||||||  ..||:.:.:   .||:: ..|||..:.              :||:.
Human    82 GGSIVSPQWVITAAHCI--ANRNIVSTLNVTAGEYDLSQTDPGEQT--------------LTIET 130

  Fly   224 ILPHAQYS---ELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGK- 284
            ::.|..:|   .::|  |||||:::....:...  :.|:|||..|.::.   ||.....:|||:
Human   131 VIIHPHFSTKKPMDY--DIALLKMAGAFQFGHF--VGPICLPELREQFE---AGFICTTAGWGRL 188

  Fly   285 TESSGSSKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAG-GEIGVDSCSGDSGGPLTVEAN 348
            ||....|::.|:..|.|...::|..|.....:.....:.:|.| .:.|.|:|.|||||.|.....
Human   189 TEGGVLSQVLQEVNLPILTWEECVAALLTLKRPISGKTFLCTGFPDGGRDACQGDSGGSLMCRNK 253

  Fly   349 TASGNRYVYLAGVVSIGRKHCGTALFS----------GIYTRVSSYMDWIESTIR-ANR 396
            ..:..    ||||.|.| ..||....:          ||:|.:|..:.||...|: .||
Human   254 KGAWT----LAGVTSWG-LGCGRGWRNNVRKSDQGSPGIFTDISKVLPWIHEHIQTGNR 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	74/275 (27%)
		Tryp_SPc	133..391	CDD:238113	75/276 (27%)
OVCH2	XP_016873148.1	Tryp_SPc	55..298	CDD:214473	74/275 (27%)
		Tryp_SPc	56..301	CDD:238113	75/277 (27%)
		CUB	320..424	CDD:238001
		CUB	435..546	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910