DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser7 and HPN

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001362370.1	Gene:	HPN / 3249	HGNCID:	5155	Length:	417	Species:	Homo sapiens

Alignment Length:	277	Identity:	90/277 - (32%)
Similarity:	133/277 - (48%)	Gaps:	43/277 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 RLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGEWN 195
            |:|||.:|.|..:||...|.|:..     :.||.|.::..|:||||||.....|     :|..|.
Human   162 RIVGGRDTSLGRWPWQVSLRYDGA-----HLCGGSLLSGDWVLTAAHCFPERNR-----VLSRWR 216

  Fly   196 RDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQY-------SELNYRNDIALLRLSRPVNWLQM 253
            ...        ..|.:.:|..:::.:..::.|..|       ||.| .|||||:.||.|:...:.
Human   217 VFA--------GAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEEN-SNDIALVHLSSPLPLTEY 272

  Fly   254 QNLEPVCLPPQRGRYANQ--LAGSAADVSGWGKTESSG-SSKIKQKAMLHIQPQDQCQEA-FYKD 314
              ::|||||.     |.|  :.|....|:|||.|:..| .:.:.|:|.:.|...|.|..| ||.:
Human   273 --IQPVCLPA-----AGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330

  Fly   315 TKITLADSQMCAG-GEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIY 378
               .:.....||| .|.|:|:|.||||||...|.:.:...|: .|.|:||.| ..|..|...|:|
Human   331 ---QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRW-RLCGIVSWG-TGCALAQKPGVY 390

  Fly   379 TRVSSYMDWIESTIRAN 395
            |:||.:.:||...|:.:
Human   391 TKVSDFREWIFQAIKTH 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	87/268 (32%)
		Tryp_SPc	133..391	CDD:238113	88/269 (33%)
HPN	NP_001362370.1	Hepsin-SRCR	51..159	CDD:401275
HPN	NP_001362370.1	Tryp_SPc	163..400	CDD:238113	86/267 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910