DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and Tmprss11b

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_795998.2	Gene:	Tmprss11b / 319875	MGIID:	2442893	Length:	416	Species:	Mus musculus

Alignment Length:	280	Identity:	92/280 - (32%)
Similarity:	136/280 - (48%)	Gaps:	52/280 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 CG-----SAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMG 183
            ||     ||...|:.||......|:||...|..    .||.| ||||.|.:|:|||||||.....
Mouse   172 CGRRPRMSATYDRITGGSTAHKGEWPWQASLRV----NGKHY-CGASLIGERFLLTAAHCFQGTN 231

  Fly   184 --RNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSR 246
              :|||.:.                 |.| ..|.:::.::..|:.|..|.:..:.:|:|:::|:.
Mouse   232 NPKNLTVSF-----------------GTR-VTPAYMQHSVQEIIIHEDYVKGEHHDDVAVIKLTE 278

  Fly   247 PVNWLQMQNLEPVCLPPQRGRYANQL--AGSAADVSGWGKTESSGSSK-IKQKAMLHIQPQDQC- 307
            .|::  ..::..||||.     :.|:  .|....|:|||....:|.|. :.|||.:.|...:.|
Mouse   279 KVSF--NNDVHRVCLPE-----STQIFPPGEGVVVTGWGSFSYNGKSPLLLQKASIKIIDTNTCN 336

  Fly   308 -QEAFYKDTKITLADSQMCAGG-EIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCG 370
             :||:..    .:.|:.:|||. |..:|:|.||||||| |..|:..   ..||.|:||.|.: ||
Mouse   337 SEEAYGG----RIVDTMLCAGYLEGSIDACQGDSGGPL-VHPNSRD---IWYLVGIVSWGHE-CG 392

  Fly   371 TALFSGIYTRVSSYMDWIES 390
            .....|:|.||:||.:||.|
Mouse   393 RVNKPGVYMRVTSYRNWIAS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	85/264 (32%)
		Tryp_SPc	133..391	CDD:238113	87/266 (33%)
Tmprss11b	NP_795998.2	SEA	46..140	CDD:279699
		Tryp_SPc	184..410	CDD:214473	85/264 (32%)
		Tryp_SPc	185..413	CDD:238113	87/267 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910