DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser7 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	110/389 - (28%)
Similarity:	165/389 - (42%)	Gaps:	79/389 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GTCIEK----KDCDFYAVDKLMELASKQQCFSRQRPDLVC------CPRETNIIPPLAPRISNGT 91
            |.|:..    |||.....::.....:..||    :.|..|      |.|:        |...||:
  Rat   468 GLCVPACDGIKDCPNGLDERNCVCRAMFQC----QEDSTCISLPRVCDRQ--------PDCLNGS 520

  Fly    92 ------TNATSSTTTLKLLPRTTPRPPS-----------GIDQLPEHPYCG-SAFSFRLVGGHNT 138
                  ......|.|.:...|:..:.|:           |.|:  ||..|| ...|.|:|||..:
  Rat   521 DEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQADCRDGSDE--EHCDCGLQGPSSRIVGGAMS 583

  Fly   139 GLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIH---TMGRNLTAAILGEWNRDTDP 200
            ...|:||...|:..    |: :.||.:.||.||::|||||..   .....|....||:..:::.
  Rat   584 SEGEWPWQASLQIR----GR-HICGGALIADRWVITAAHCFQEDSMASPRLWTVFLGKMRQNSR- 642

  Fly   201 DCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQR 265
                        .|..:...:.|:..|..:.|.::..|:|||:|..||  :....:.|||||.:.
  Rat   643 ------------WPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPV--VYSATVRPVCLPARS 693

  Fly   266 GRYANQLAGSAADVSGWGKTESSG-SSKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAGGE 329
            ..:.   .|....::|||.....| .|...||..:.:.|||.|.||:    :..:....:|||..
  Rat   694 HFFE---PGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEAY----RYQVTPRMLCAGYR 751

  Fly   330 IG-VDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIESTI 392
            .| .|:|.|||||||.  ....|| |: :|||:||.| ..||...|.|:||||:..::||:..:
  Rat   752 KGKKDACQGDSGGPLV--CKEPSG-RW-FLAGLVSWG-LGCGRPNFFGVYTRVTRVVNWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	9/46 (20%)
		Tryp_SPc	131..388	CDD:214473	83/261 (32%)
		Tryp_SPc	133..391	CDD:238113	84/262 (32%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060	5/20 (25%)
		LDLa	495..525	CDD:238060	9/41 (22%)
		Ldl_recept_a	529..566	CDD:278486	7/38 (18%)
		Tryp_SPc	576..806	CDD:214473	83/261 (32%)
		Tryp_SPc	577..809	CDD:238113	84/263 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910