DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and GZMH

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_219491.1	Gene:	GZMH / 2999	HGNCID:	4710	Length:	246	Species:	Homo sapiens

Alignment Length:	266	Identity:	72/266 - (27%)
Similarity:	117/266 - (43%)	Gaps:	46/266 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGEWNR 196
            ::|||.......|:...:::......|  .||...:.:.::||||||   .|.::... ||..|
Human    21 IIGGHEAKPHSRPYMAFVQFLQEKSRK--RCGGILVRKDFVLTAAHC---QGSSINVT-LGAHN- 78

  Fly   197 DTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCL 261
                        ::|.......:.:.|.:||..|:..|:.|||.||:|.|...|...  :.|:.|
Human    79 ------------IKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTA--VRPLRL 129

  Fly   262 PPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAMLHIQPQDQCQEAFY----KDTKITLADS 322
            |..:   |....|....|:|||....|..:...|:.:|.:|...||:..|:    :.|:|.:.|.
Human   130 PSSK---AQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRATEICVGDP 191

  Fly   323 QMCAGGEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDW 387
            :....|      ..|||||||..: :.|.        |::|.|.|. ||.  .|:|.:||.::.|
Human   192 KKTQTG------FKGDSGGPLVCK-DVAQ--------GILSYGNKK-GTP--PGVYIKVSHFLPW 238

  Fly   388 IESTIR 393
            |:.|::
Human   239 IKRTMK 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	69/259 (27%)
		Tryp_SPc	133..391	CDD:238113	71/261 (27%)
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	71/262 (27%)
GZMH	NP_219491.1	Mediates the preference for acidic residues at the P3' and P4' sites	46..48		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910