DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and F2

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	124/525 - (23%)
Similarity:	183/525 - (34%)	Gaps:	167/525 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTLLGAEAQQFGKAIMHFGNCNSVEFGRGTCIEKKDCD----------FYAVDKLM--ELASKQQ 61
            :|..|.|.|.:.....|..:.||... .|..:::..|.          .|..|..:  |..|...
  Rat   123 VTHTGIECQLWRSRYPHRPDINSTTH-PGADLKENFCRNPDSSTSGPWCYTTDPTVRREECSIPV 186

  Fly    62 CFSRQRPDLVCCPR----ETNIIPPLAP------RISNGTTNATS-----------STTTL---- 101
            |....|..:...||    :.|:.|||..      |:..|....|:           .|.||
  Rat   187 CGQEGRTTVKMTPRSRGSKENLSPPLGECLLERGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQ 251

  Fly   102 ------KLLP---RTTPRPPSG----IDQLPEHPYCGSAFSFRLVGGHN---------------- 137
                  ||:.   |...|...|    :.|.|...||...:....||..|
  Rat   252 NFDPEVKLVQNFCRNPDRDEEGAWCFVAQQPGFEYCSLNYCDEAVGEENHDGDESIAGRTTDAEF 316

  Fly   138 ------------------TGLFE-------------------------------FPWTTLLEYET 153
                              ..|||                               .||..:|..::
  Rat   317 HTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKS 381

  Fly   154 VSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIR 218
               .::..||||.|:.||:|||||||          :...|:::.   .||||. ||  ...|.|
  Rat   382 ---PQELLCGASLISDRWVLTAAHCI----------LYPPWDKNF---TENDLL-VR--IGKHSR 427

  Fly   219 V----------TIDRILPHAQYS-ELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQL 272
            .          .:::|..|.:|: ..|...|||||:|.:||.:  ...:.|||||.::...:...
  Rat   428 TRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPF--SDYIHPVCLPDKQTVTSLLQ 490

  Fly   273 AGSAADVSGWGKTESSGSSKIK-------QKAMLHIQPQDQCQEAFYKDTKITLADSQMCAGGEI 330
            ||....|:|||....:.::.|.       |...|.|..:..|:.:    |:|.:.|:..|||.::
  Rat   491 AGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKAS----TRIRITDNMFCAGFKV 551

  Fly   331 G----VDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIEST 391
            .    .|:|.||||||..::   :..|...|..|:||.| :.|......|.||.|.....|::..
  Rat   552 NDTKRGDACEGDSGGPFVMK---SPYNHRWYQMGIVSWG-EGCDRNGKYGFYTHVFRLKRWMQKV 612

  Fly   392 IRANR 396
            |..:|
  Rat   613 IDQHR 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	10/56 (18%)
		Tryp_SPc	131..388	CDD:214473	85/343 (25%)
		Tryp_SPc	133..391	CDD:238113	86/344 (25%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527	14/66 (21%)
		Kringle	215..292	CDD:278480	15/76 (20%)
		Thrombin_light	312..359	CDD:286482	3/46 (7%)
		Tryp_SPc	359..608	CDD:214473	79/277 (29%)
		Tryp_SPc	360..612	CDD:238113	80/280 (29%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		10/21 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910