DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and KLK9

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_036447.1	Gene:	KLK9 / 284366	HGNCID:	6370	Length:	250	Species:	Homo sapiens

Alignment Length:	278	Identity:	83/278 - (29%)
Similarity:	109/278 - (39%)	Gaps:	73/278 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 RLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGE-- 193
            |.:|.........||...|.:.|     ...|||:.|:.|||||||||    .:......|||
Human    22 RAIGAEECRPNSQPWQAGLFHLT-----RLFCGATLISDRWLLTAAHC----RKPYLWVRLGEHH 77

  Fly   194 -WNRDTDPDCENDLNGVRECAPPHI-RVTIDRILPHAQY----SELNYRNDIALLRLSRPVNW-- 250
             |..:               .|..: |||  ...||..:    |..::.:||.|:||.|....
Human    78 LWKWE---------------GPEQLFRVT--DFFPHPGFNKDLSANDHNDDIMLIRLPRQARLSP 125

  Fly   251 -LQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAMLHIQPQDQCQEAFYKD 314
             :|..||...|:.|          |....:||||...|       .||:..:..  ||......:
Human   126 AVQPLNLSQTCVSP----------GMQCLISGWGAVSS-------PKALFPVTL--QCANISILE 171

  Fly   315 TKIT-------LADSQMCAG-GEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGT 371
            .|:.       ::||.:||| .|.|..||.|||||||.....         ||||||.|.:.|..
Human   172 NKLCHWAYPGHISDSMLCAGLWEGGRGSCQGDSGGPLVCNGT---------LAGVVSGGAEPCSR 227

  Fly   372 ALFSGIYTRVSSYMDWIE 389
            .....:||.|..|:|||:
Human   228 PRRPAVYTSVCHYLDWIQ 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	81/275 (29%)
		Tryp_SPc	133..391	CDD:238113	82/276 (30%)
KLK9	NP_036447.1	Tryp_SPc	24..247	CDD:238113	82/276 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910