DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser7 and F10

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	405	Identity:	105/405 - (25%)
Similarity:	171/405 - (42%)	Gaps:	74/405 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GNCNSVEFGRGTC-----IEKKDCDFYAVDKLMELAS---KQQCFSRQRPDLVCCPRETNIIP-- 81
            |.|.. ..|..||     .|.|:|:.: ..||..|.:   .|.|...|...:..|.|...:..
Human    99 GKCKD-GLGEYTCTCLEGFEGKNCELF-TRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNG 161

  Fly    82 ----PLAP---------RISNGTTNATSS------TTTLK------LLPRTTPRPPSGIDQLPEH 121
                |..|         |.......||||      :.|.|      |.|  |..|...:|.....
Human   162 KACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDP--TENPFDLLDFNQTQ 224

  Fly   122 PYCGSAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNL 186
            |..|.....|:|||......|.||..||..|...|    .||.:.:::.::||||||::...|
Human   225 PERGDNNLTRIVGGQECKDGECPWQALLINEENEG----FCGGTILSEFYILTAAHCLYQAKR-- 283

  Fly   187 TAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWL 251
            ....:|:.|.:.:...|    .|.|         ::.::.|.::::..|..|||:|||..|:.:
Human   284 FKVRVGDRNTEQEEGGE----AVHE---------VEVVIKHNRFTKETYDFDIAVLRLKTPITF- 334

  Fly   252 QMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSG--SSKIKQKAMLHIQPQDQCQEAFYKD 314
             ..|:.|.|||.:....:..:......|||:|:|...|  |:::|...:.::. ::.|:    ..
Human   335 -RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVD-RNSCK----LS 393

  Fly   315 TKITLADSQMCAGGEI-GVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIY 378
            :...:..:..|||.:. ..|:|.||||||..    |...:.| ::.|:||.| :.|......|||
Human   394 SSFIITQNMFCAGYDTKQEDACQGDSGGPHV----TRFKDTY-FVTGIVSWG-EGCARKGKYGIY 452

  Fly   379 TRVSSYMDWIESTIR 393
            |:|::::.||:.:::
Human   453 TKVTAFLKWIDRSMK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	13/52 (25%)
		Tryp_SPc	131..388	CDD:214473	71/259 (27%)
		Tryp_SPc	133..391	CDD:238113	72/260 (28%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011	7/23 (30%)
		FXa_inhibition	129..164	CDD:317114	6/34 (18%)
		O-glycosylated at one site	183..203		6/19 (32%)
		Tryp_SPc	235..464	CDD:238113	72/260 (28%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920