DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser7 and Tmprss13

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_006510195.1	Gene:	Tmprss13 / 214531	MGIID:	2682935	Length:	561	Species:	Mus musculus

Alignment Length:	457	Identity:	124/457 - (27%)
Similarity:	195/457 - (42%)	Gaps:	116/457 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLLIPLFLTLL----GAEAQQFGKAIMHFGNCNSVEFGRG-TCIEKKD----CDFYAV--DKLM 54
            ::|||.|.::|:    |.|.|.        ....:|.|.|| |.|:.|:    |..:||  |.::
Mouse   153 VILLISLVISLILLYGGRETQS--------PRGTAVYFWRGHTGIKYKEPLESCPIHAVRCDGVV 209

  Fly    55 ELASKQQCFSRQRPDLVCCPR---ETNIIPPLAPRISNGTT-----------NATSSTTTLKLLP 105
            :      |  :.:.|.:.|.|   :.:::     ::.:|::           |.|.|..|.:.|.
Mouse   210 D------C--KMKSDELGCVRFDWDKSLL-----KVYSGSSGEWLPVCSSSWNDTDSKRTCQQLG 261

  Fly   106 -----RTTPRPPSGI-------------------DQLPEHPY-------CG-SAFSFRLVGGHNT 138
                 |||......|                   .|.|...|       || .|.:.|:|||..|
Mouse   262 FDSAYRTTEVAHRDITSSFLLSEYNTTIQESLYRSQCPSRRYVSLQCSHCGLRAMTGRIVGGALT 326

  Fly   139 GLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGEWNRDTDPDCE 203
            ...::||...|.:     |..:.||.:.|..:|:||||||.......|    |..|.....   .
Mouse   327 SESKWPWQVSLHF-----GTTHICGGTLIDAQWVLTAAHCFFVTREKL----LEGWKVYAG---T 379

  Fly   204 NDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRY 268
            ::|:.:.|.|      :|.:|:.:..|::.....||||:|||:|:.  ...::.|.|||.....:
Mouse   380 SNLHQLPEAA------SISQIIINGNYTDEQDDYDIALIRLSKPLT--LSAHIHPACLPMHGQTF 436

  Fly   269 ANQLAGSAADVSGWGKTESSG--SSKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAGG-EI 330
            .   ......::|:|||:.:.  :|...::..:::....:|.:....|:.:|  ...||||. ..
Mouse   437 G---LNETCWITGFGKTKETDEKTSPFLREVQVNLIDFKKCNDYLVYDSYLT--PRMMCAGDLRG 496

  Fly   331 GVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWI----EST 391
            |.|||.|||||||..|.|    ||: |||||.|.| ..||.....|:||:|:..:.||    ||.
Mouse   497 GRDSCQGDSGGPLVCEQN----NRW-YLAGVTSWG-TGCGQKNKPGVYTKVTEVLPWIYRKMESE 555

  Fly   392 IR 393
            :|
Mouse   556 VR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	13/51 (25%)
		Tryp_SPc	131..388	CDD:214473	80/259 (31%)
		Tryp_SPc	133..391	CDD:238113	82/264 (31%)
Tmprss13	XP_006510195.1	PHA03378	<6..>122	CDD:223065
		LDLa	<204..220	CDD:238060	3/23 (13%)
		SRCR_2	225..314	CDD:373897	15/93 (16%)
		Tryp_SPc	319..548	CDD:214473	80/259 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910