DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and Tmprss4

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_663378.1	Gene:	Tmprss4 / 214523	MGIID:	2384877	Length:	435	Species:	Mus musculus

Alignment Length:	373	Identity:	94/373 - (25%)
Similarity:	154/373 - (41%)	Gaps:	111/373 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DKLMELASKQQCFSRQ--------RPDLVCCPRETNIIPPLAP--------RISNGTTNATS-ST 98
            :.|.:.|.:|..:..|        |||       .|:  |:|.        ::.||:.:..| |.
Mouse   131 EALAKTACRQMGYDSQPAFRAVEIRPD-------QNL--PVAQVTGNSQELQVQNGSRSCLSGSL 186

  Fly    99 TTLKLLPRTTPRPPSGIDQLPEHPYCGSAFSF-RLVGGHNTGLFEFPWTTLLEYETVSGGKDYAC 162
            .:|:.|.                  ||.:... |:|||....:..:||...::|     .|.:.|
Mouse   187 VSLRCLD------------------CGKSLKTPRVVGGVEAPVDSWPWQVSIQY-----NKQHVC 228

  Fly   163 GASFIAQRWLLTAAHCIH----------TMGRNLTAAILGEWNRDTDPDCENDLNGVRECAP--P 215
            |.|.:...|:||||||..          ..|.|    |||.                   :|  |
Mouse   229 GGSILDPHWILTAAHCFRKYLDVSSWKVRAGSN----ILGN-------------------SPSLP 270

  Fly   216 HIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLAGSAAD-- 278
            ..::.|..  |:..|.:   ..||||::|..|:.:  ..::.|:|||     :::::...|..
Mouse   271 VAKIFIAE--PNPLYPK---EKDIALVKLQMPLTF--SGSVRPICLP-----FSDEVLVPATPVW 323

  Fly   279 VSGWGKTESSGS--SKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAG-GEIGVDSCSGDSG 340
            |.|||.||.:|.  |.:..:|.:.:....:|......:.::|.  ..:||| .:.|.|:|.||||
Mouse   324 VIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTA--EMLCAGTPQGGKDTCQGDSG 386

  Fly   341 GPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWI 388
            |||...::...      :.|:||.|. .||.....|:||:|::|::||
Mouse   387 GPLMYHSDKWQ------VVGIVSWGH-GCGGPSTPGVYTKVTAYLNWI 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	7/30 (23%)
		Tryp_SPc	131..388	CDD:214473	74/273 (27%)
		Tryp_SPc	133..391	CDD:238113	75/273 (27%)
Tmprss4	NP_663378.1	LDLa	56..90	CDD:238060
		SRCR_2	106..195	CDD:295335	16/90 (18%)
		Tryp_SPc	202..427	CDD:214473	74/273 (27%)
		Tryp_SPc	203..430	CDD:238113	75/274 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910