DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and C1s

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_620255.2	Gene:	C1s / 192262	RGDID:	619983	Length:	694	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	115/409 - (28%)
Similarity:	170/409 - (41%)	Gaps:	96/409 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GNCNSVEFGRGTCIEKKDCDFYAVDKLMELASKQQCFSRQRPDLVCCPRETNIIPPLAPRISNGT 91
            ||..|..| ..||                 .|..| :|..|  |.|.|.:..:..|    |.||.
  Rat   336 GNVGSTSF-YSTC-----------------QSNGQ-WSNSR--LECQPVDCGVPEP----IENGK 375

  Fly    92 TNATSSTTTLKLLPRTTPRPPSGIDQ----------------------LPE-HPYCG---SAFSF 130
            ......|....::..|...|...::|                      ||: .|.||   ..|..
  Rat   376 VEDPEDTVFGSVIHYTCEEPYYYMEQEEGGEYHCAANGSWVNDQLGVELPKCIPVCGVPTEPFKV 440

  Fly   131 --RLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGE 193
              |:.||::|.:..|||.  :.:|:..|      |.:.|.:.|:|||||.:             |
  Rat   441 QQRIFGGYSTKIQSFPWQ--VYFESPRG------GGALIDEYWVLTAAHVV-------------E 484

  Fly   194 WNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSE-------LNYRNDIALLRLSRPVNWL 251
            .|.|......:.|..:....... |:..:|::.|..:.:       .|:.|||||::|..||.
  Rat   485 GNSDPVMYVGSTLLKIERLRNAQ-RLITERVIIHPSWKQEDDLNTRTNFDNDIALVQLKDPVK-- 546

  Fly   252 QMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAMLHIQPQDQCQEAFYKDTK 316
            ....:.|:|||.....| |...|....:||||:||:..:....:.|.|.|...::||:...::.|
  Rat   547 MGPTVAPICLPETSSDY-NPSEGDLGLISGWGRTENRTNVIQLRGAKLPITSLEKCQQVKVENPK 610

  Fly   317 -----ITLADSQMCAGGEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSG 376
                 ....|:.:|| ||.|||||.|||||...:........:: |:||:||.|:| |||   .|
  Rat   611 ARSNDYVFTDNMICA-GEKGVDSCEGDSGGAFALPVPNVKDPKF-YVAGLVSWGKK-CGT---YG 669

  Fly   377 IYTRVSSYMDWIESTIRAN 395
            |||:|.:|:|||..|::.|
  Rat   670 IYTKVKNYVDWILKTMQEN 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	10/44 (23%)
		Tryp_SPc	131..388	CDD:214473	84/268 (31%)
		Tryp_SPc	133..391	CDD:238113	85/269 (32%)
C1s	NP_620255.2	CUB	24..135	CDD:238001
		FXa_inhibition	149..177	CDD:405372
		CUB	181..293	CDD:395345
		CCP	300..361	CDD:153056	11/45 (24%)
		CCP	365..428	CDD:153056	10/66 (15%)
		Tryp_SPc	443..681	CDD:214473	84/268 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BFCY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900