DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and Tmprss15

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_032967.1	Gene:	Tmprss15 / 19146	MGIID:	1197523	Length:	1069	Species:	Mus musculus

Alignment Length:	424	Identity:	110/424 - (25%)
Similarity:	171/424 - (40%)	Gaps:	107/424 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CNSVEF--GRGTCIEKKD-CDFYAVDKLMELASKQQCFSRQRPDLVCCPRETNIIPPLAPRISNG 90
            |...||  ..|.||...: ||.|           ..|  |...|...|.|..|     ..|.:||
Mouse   688 CQDDEFQCKDGNCIPLGNLCDSY-----------PHC--RDGSDEASCVRFLN-----GTRSNNG 734

  Fly    91 ------------------TTNATS---------STTTLKLLPRTTPRPPSGIDQLP--------- 119
                              ||..::         |..:...:..|...|...::|.|
Mouse   735 LVQFNIHSIWHIACAENWTTQISNEVCHLLGLGSANSSMPISSTGGGPFVRVNQAPNGSLILTPS 799

  Fly   120 -------------EHPYCG-----SAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASF 166
                         .|..||     ...|.::|||.:.....:||...|.:...|..: ..||||.
Mouse   800 LQCSQDSLILLQCNHKSCGEKKVTQKVSPKIVGGSDAQAGAWPWVVALYHRDRSTDR-LLCGASL 863

  Fly   167 IAQRWLLTAAHCIHTMGRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYS 231
            ::..||::||||::.  |||...   .|........:::|.     :|..:|..:|:|:.:..|.
Mouse   864 VSSDWLVSAAHCVYR--RNLDPT---RWTAVLGLHMQSNLT-----SPQVVRRVVDQIVINPHYD 918

  Fly   232 ELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQ--LAGSAADVSGWG--KTESSGSSK 292
            .....||||::.|...||:...  ::|:|||.:     ||  :.|....::|||  |..:..:..
Mouse   919 RRRKVNDIAMMHLEFKVNYTDY--IQPICLPEE-----NQIFIPGRTCSIAGWGYDKINAGSTVD 976

  Fly   293 IKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAG-GEIGVDSCSGDSGGPLTVEANTASGNRYV 356
            :.::|.:.:...::||:..   .:..:.:|.:||| .|.|:|||.|||||||..:.|    ||:
Mouse   977 VLKEADVPLISNEKCQQQL---PEYNITESMICAGYEEGGIDSCQGDSGGPLMCQEN----NRW- 1033

  Fly   357 YLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIES 390
            :|.||.|.| ..|......|:|.|||.:::||.|
Mouse  1034 FLVGVTSFG-VQCALPNHPGVYVRVSQFIEWIHS 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	12/47 (26%)
		Tryp_SPc	131..388	CDD:214473	78/261 (30%)
		Tryp_SPc	133..391	CDD:238113	81/263 (31%)
Tmprss15	NP_032967.1	SEA	53..154	CDD:214554
		LDLa	228..261	CDD:197566
		CUB	270..376	CDD:294042
		MAM	392..549	CDD:279023
		MAM	392..547	CDD:99706
		CUB	569..676	CDD:278839
		LDLa	688..722	CDD:238060	12/46 (26%)
		SR	723..816	CDD:214555	13/97 (13%)
		SRCR	728..819	CDD:278931	12/90 (13%)
		Tryp_SPc	829..1064	CDD:214473	78/261 (30%)
		Tryp_SPc	830..1066	CDD:238113	80/262 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910