DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and St14

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_036010597.1	Gene:	St14 / 19143	MGIID:	1338881	Length:	875	Species:	Mus musculus

Alignment Length:	394	Identity:	110/394 - (27%)
Similarity:	167/394 - (42%)	Gaps:	102/394 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GKAIMHFGNCNSVEFGRGTCIEKKD---CDFYAVDKLMELASKQQ---CFSRQRPDLVCCPRETN 78
            ||.:.....||    |:..|.:..|   ||...|....:...:.|   |.|:..|:   |..:|:
Mouse   555 GKCLPQSQKCN----GKDNCGDGSDEASCDSVNVVSCTKYTYRCQNGLCLSKGNPE---CDGKTD 612

  Fly    79 IIPPLAPRISNGTTNATSSTTTLKLLPRTTPRPPSGIDQLPEHPYCGSAFSF----RLVGGHNTG 139
                    .|:|:......                          ||.. ||    |:|||.|..
Mouse   613 --------CSDGSDEKNCD--------------------------CGLR-SFTKQARVVGGTNAD 642

  Fly   140 LFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCI----------HTMGRNLTAAILGEW 194
            ..|:||...|.    :.|:.:.||||.|:..||::||||.          :||    ..|.||..
Mouse   643 EGEWPWQVSLH----ALGQGHLCGASLISPDWLVSAAHCFQDDKNFKYSDYTM----WTAFLGLL 699

  Fly   195 NRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPV 259
            ::.     :...:||:|       :.:.||:.|..:::..:..|||||.|.:.|.:..:  :.|:
Mouse   700 DQS-----KRSASGVQE-------LKLKRIITHPSFNDFTFDYDIALLELEKSVEYSTV--VRPI 750

  Fly   260 CLPPQRGRYANQLAGSAADVSGWGKTESSGS-SKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQ 323
            |||.....:.   ||.|..|:|||.|:..|: :.|.||..:.:..|..|::...:.    :....
Mouse   751 CLPDATHVFP---AGKAIWVTGWGHTKEGGTGALILQKGEIRVINQTTCEDLMPQQ----ITPRM 808

  Fly   324 MCAG---GEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYM 385
            ||.|   |  |||||.|||||||    ::|..:..::.|||||.| :.|......|:|||:....
Mouse   809 MCVGFLSG--GVDSCQGDSGGPL----SSAEKDGRMFQAGVVSWG-EGCAQRNKPGVYTRLPVVR 866

  Fly   386 DWIE 389
            |||:
Mouse   867 DWIK 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	12/50 (24%)
		Tryp_SPc	131..388	CDD:214473	86/270 (32%)
		Tryp_SPc	133..391	CDD:238113	87/271 (32%)
St14	XP_036010597.1	SEA	108..198	CDD:396113
		CUB	247..352	CDD:238001
		CUB	360..464	CDD:238001
		LDLa	474..506	CDD:238060
		LDLa	512..543	CDD:238060
		LDLa	545..579	CDD:238060	7/27 (26%)
		LDLa	587..622	CDD:238060	8/45 (18%)
		Tryp_SPc	635..872	CDD:238113	87/272 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910