DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser7 and Prss12

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	396	Identity:	107/396 - (27%)
Similarity:	151/396 - (38%)	Gaps:	107/396 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GKAIMHFGN------------CNSVEFGRGTCIEKKD----CDFYAVDKLMELASKQQCFSRQRP 68
            ||..:|..|            |...:.||..|...:|    ||:     |.:.||
Mouse   444 GKGPIHMDNVKCTGNEKALADCVKQDIGRHNCRHSEDAGVICDY-----LEKKAS---------- 493

  Fly    69 DLVCCPRETNIIPPLAPRISNGTTNATSSTTTLKLLPRTTPRPPSGIDQLPEHPYCGSAFSFRLV 133
                               |:|.....||...|:||.|...                     |::
Mouse   494 -------------------SSGNKEMLSSGCGLRLLHRRQK---------------------RII 518

  Fly   134 GGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLT--AAILGEWNR 196
            ||:|:....:||...|...:..|.....|||:.::..|:||||||....|.|..  |..:|:::.
Mouse   519 GGNNSLRGAWPWQASLRLRSAHGDGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRVGDYHT 583

  Fly   197 DTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLE---- 257
            ....:.|.::.             :.:|:.|..|.......||||:||..|..  |...|.
Mouse   584 LVPEEFEQEIG-------------VQQIVIHRNYRPDRSDYDIALVRLQGPGE--QCARLSTHVL 633

  Fly   258 PVCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAMLHIQPQDQCQEAFYKDTKITLADS 322
            |.|||..|.|  .|...|...::|||.| ....|:..|:|.:.:.|:..|:|.:    |......
Mouse   634 PACLPLWRER--PQKTASNCHITGWGDT-GRAYSRTLQQAAVPLLPKRFCKERY----KGLFTGR 691

  Fly   323 QMCAGG---EIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSY 384
            .:|||.   :..||||.|||||||..|....|...|    ||.|.| ..||.....|:||||.::
Mouse   692 MLCAGNLQEDNRVDSCQGDSGGPLMCEKPDESWVVY----GVTSWG-YGCGVKDTPGVYTRVPAF 751

  Fly   385 MDWIES 390
            :.||:|
Mouse   752 VPWIKS 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	10/48 (21%)
		Tryp_SPc	131..388	CDD:214473	82/265 (31%)
		Tryp_SPc	133..391	CDD:238113	84/267 (31%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555	9/40 (23%)
		SRCR	396..485	CDD:278931	9/40 (23%)
		Zymogen activation region	505..516		4/31 (13%)
		Tryp_SPc	516..755	CDD:214473	82/265 (31%)
		Tryp_SPc	517..758	CDD:238113	84/268 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910