DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and Hpn

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001263198.1	Gene:	Hpn / 15451	MGIID:	1196620	Length:	445	Species:	Mus musculus

Alignment Length:	408	Identity:	109/408 - (26%)
Similarity:	164/408 - (40%)	Gaps:	112/408 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LGAEAQQFGKAIMHFGNCNSVEFGRGTCIEKKDCDFYAVD--------KLMELASKQQCFSRQRP 68
            ||.|...|.:|:.|      .|....|........|:.||        :|:::.|
Mouse   116 LGCEEMGFLRALAH------SELDVRTAGANGTSGFFCVDEGGLPLAQRLLDVIS---------- 164

  Fly    69 DLVC-CPRETNIIPPLAPRISNGTTNATSSTTTLKLLPRTTPRPPSGIDQLPEHPYCGSAFSFRL 132
              || |||...:             .||......:.||         :|              |:
Mouse   165 --VCDCPRGRFL-------------TATCQDCGRRKLP---------VD--------------RI 191

  Fly   133 VGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGEWNRD 197
            |||.::.|..:||...|.|:..     :.||.|.::..|:||||||.....|     :|..|...
Mouse   192 VGGQDSSLGRWPWQVSLRYDGT-----HLCGGSLLSGDWVLTAAHCFPERNR-----VLSRWRVF 246

  Fly   198 TDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYR--------NDIALLRLSR--PVNWLQ 252
            .        ..|...:|..:::.:..::.|..|  |.:|        |||||:.||.  |:.
Mouse   247 A--------GAVARTSPHAVQLGVQAVIYHGGY--LPFRDPTIDENSNDIALVHLSSSLPLT--- 298

  Fly   253 MQNLEPVCLPPQRGRYANQ--LAGSAADVSGWGKTESSG-SSKIKQKAMLHIQPQDQCQEA-FYK 313
             :.::|||||.     |.|  :.|....|:|||.|:..| .:.:.|:|.:.|...:.|... ||.
Mouse   299 -EYIQPVCLPA-----AGQALVDGKVCTVTGWGNTQFYGQQAMVLQEARVPIISNEVCNSPDFYG 357

  Fly   314 DTKITLADSQMCAG-GEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGI 377
            :   .:.....||| .|.|:|:|.||||||...| ::.||.....|.|:||.| ..|..|...|:
Mouse   358 N---QIKPKMFCAGYPEGGIDACQGDSGGPFVCE-DSISGTSRWRLCGIVSWG-TGCALARKPGV 417

  Fly   378 YTRVSSYMDWIESTIRAN 395
            ||:|:.:.:||...|:.:
Mouse   418 YTKVTDFREWIFKAIKTH 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	9/53 (17%)
		Tryp_SPc	131..388	CDD:214473	83/271 (31%)
		Tryp_SPc	133..391	CDD:238113	84/272 (31%)
Hpn	NP_001263198.1	Hepsin-SRCR	78..187	CDD:255261	20/101 (20%)
		Tryp_SPc	190..428	CDD:214473	83/271 (31%)
		Tryp_SPc	191..428	CDD:238113	82/270 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910