DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and F10

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001229297.1	Gene:	F10 / 14058	MGIID:	103107	Length:	493	Species:	Mus musculus

Alignment Length:	415	Identity:	112/415 - (26%)
Similarity:	174/415 - (41%)	Gaps:	95/415 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GNCNSVEFGRGTC-----IEKKDCDFYAVDKLMELASKQQC--FSRQRPDLVCCPRET------- 77
            |.|.. ..|..||     .|.|:|:.: |.||..| ....|  |.|:..:.|.|...:
Mouse   111 GACRD-GIGGYTCTCSEGFEGKNCELF-VRKLCRL-DNGDCDQFCREEQNSVVCSCASGYFLGND 172

  Fly    78 -----NIIPPLAPRISNG------TTNATSSTTTLK--------LLPRTTP---------RPPSG 114
                 :..|....:|:.|      ..|.:.|...|:        |.|...|         :|...
Mouse   173 GKSCISTAPFPCGKITTGRRKRSVALNTSDSELDLEDALLDEDFLSPTENPIELLNLNETQPERS 237

  Fly   115 IDQLPEHPYCGSAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCI 179
            .|.|           .|:|||......|.||..||..|...|    .||.:.:.:.::||||||:
Mouse   238 SDDL-----------VRIVGGRECKDGECPWQALLINEDNEG----FCGGTILNEFYILTAAHCL 287

  Fly   180 HTMGRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRL 244
            | ..|.....:   .:|:|:.:..|::  |.|         :|.::.|.::....|..|||:|||
Mouse   288 H-QARRFKVRV---GDRNTEKEEGNEM--VHE---------VDVVIKHNKFQRDTYDYDIAVLRL 337

  Fly   245 SRPVNWLQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSG--SSKIKQKAMLHIQPQDQ- 306
            ..|:.:  ..|:.|.|||.:....:..:......|||:|:|...|  |:.:|   ||.:...|:
Mouse   338 KTPITF--RMNVAPACLPQKDWAESTLMTQKTGIVSGFGRTHEKGRQSNILK---MLEVPYVDRN 397

  Fly   307 -CQEAFYKDTKITLADSQMCAGGEIGV-DSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHC 369
             |:    ..|..::..:..|||.|..: |:|.||||||..    |...|.| |:.|:||.| :.|
Mouse   398 TCK----LSTSFSITQNMFCAGYEAKLEDACQGDSGGPHV----TRFKNTY-YVTGIVSWG-EGC 452

  Fly   370 GTALFSGIYTRVSSYMDWIESTIRA 394
            ......||||:|::::.||:.:::|
Mouse   453 ARKGKYGIYTKVTTFLKWIDRSMKA 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	15/51 (29%)
		Tryp_SPc	131..388	CDD:214473	80/261 (31%)
		Tryp_SPc	133..391	CDD:238113	81/262 (31%)
F10	NP_001229297.1	GLA	36..97	CDD:214503
		EGF_CA	98..134	CDD:238011	7/23 (30%)
		FXa_inhibition	141..176	CDD:291342	6/35 (17%)
		Tryp_SPc	243..471	CDD:214473	80/261 (31%)
		Tryp_SPc	244..473	CDD:238113	81/262 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910