DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and TMPRSS11B

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_872308.2	Gene:	TMPRSS11B / 132724	HGNCID:	25398	Length:	416	Species:	Homo sapiens

Alignment Length:	264	Identity:	81/264 - (30%)
Similarity:	127/264 - (48%)	Gaps:	39/264 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 RLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAAILGEWN 195
            ::|.|.::....:||...::::    |:.| ||||.|:.||||:||||......:      .:|.
Human   184 KIVNGKSSLEGAWPWQASMQWK----GRHY-CGASLISSRWLLSAAHCFAKKNNS------KDWT 237

  Fly   196 RDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVC 260
                      :|.......|::...:..|:.|..||.....:||||::|:..|::.:.  :..:|
Human   238 ----------VNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEY--IRKIC 290

  Fly   261 LPPQRGRYANQLAGSAADVSGWGKTESSGS-SKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQM 324
            ||..:.:.:.   .....|:|||....:|| ..|.|:..|.|.....|..::.....:|  |:.:
Human   291 LPEAKMKLSE---NDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVT--DTML 350

  Fly   325 CAG---GEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMD 386
            |||   ||  .|:|..||||||   |...|.|.: :|.|:||.| ..||.....|:||||:||.:
Human   351 CAGFMSGE--ADACQNDSGGPL---AYPDSRNIW-HLVGIVSWG-DGCGKKNKPGVYTRVTSYRN 408

  Fly   387 WIES 390
            ||.|
Human   409 WITS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	78/260 (30%)
		Tryp_SPc	133..391	CDD:238113	81/262 (31%)
TMPRSS11B	NP_872308.2	SEA	45..143	CDD:279699
		Tryp_SPc	184..410	CDD:214473	78/260 (30%)
		Tryp_SPc	185..413	CDD:238113	81/263 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910