DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and Cfi

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_031712.2	Gene:	Cfi / 12630	MGIID:	105937	Length:	603	Species:	Mus musculus

Alignment Length:	422	Identity:	113/422 - (26%)
Similarity:	167/422 - (39%)	Gaps:	122/422 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GKAIMHFGNCNSVEFGRGTCIEKKDCDFYAVDKLMELASK------QQCFSRQRPDLVCCP---- 74
            ||.|.....||.|          .||.    |:..||..|      ..|.|.     ||.|
Mouse   237 GKHIPQEKACNGV----------NDCG----DQSDELCCKGCRGNASLCKSG-----VCIPDQYK 282

  Fly    75 -------------------RETNIIPPLAPRISNGTTNATSSTTTLKLLPRTTPRPPSGIDQ--- 117
                               |:.||...|| |.:.|.....:..|.:     .||    |:|.
Mouse   283 CNGEVDCITGEDESRCEEDRQQNIPKGLA-RSAQGEAEIETEETEM-----LTP----GMDNERK 337

  Fly   118 -----LPEHPYCGSAFSF-----RLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWL 172
                 ||:.. ||...:.     |::||....:.::||..     .:..|:...||..:|...|:
Mouse   338 RIKSLLPKLS-CGVKRNTHTRRKRVIGGKPANVGDYPWQV-----AIKDGQRITCGGIYIGGCWI 396

  Fly   173 LTAAHCI-----HTMGRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSE 232
            ||||||:     |:.  .:..|:| :|.:      .|...|::         |:.|::.|.:|:.
Mouse   397 LTAAHCVRPSRAHSY--QVWTALL-DWLK------PNSQLGIQ---------TVKRVIVHEKYNG 443

  Fly   233 LNYRNDIALLRLSRPV--NWLQMQNLEPVCLP--PQRGRYANQLAGSAADVSGWGKTESSGSSKI 293
            ..::|||||:.:....  ...::.|..|.|:|  |    |..| ......:||||:  ...:.|:
Mouse   444 ATFQNDIALIEMKMHTGKKECELPNSVPACVPWSP----YLFQ-PNDRCIISGWGR--GKDNQKV 501

  Fly   294 KQKAMLHIQPQDQCQEAFYKDTKITLADSQM-CAGGEIG-VDSCSGDSGGPLTVEANTASGNRYV 356
            .......:.....|.: ||.|   ...:.:| |||...| :|:|.|||||||..|    ..|...
Mouse   502 YSLRWGEVDLIGNCSQ-FYPD---RYYEKEMQCAGTRDGSIDACKGDSGGPLVCE----DINNVT 558

  Fly   357 YLAGVVSIGRKHCGTALFSGIYTRVSSYMDWI 388
            |:.|:||.| ::||...|.|:||||::|.|||
Mouse   559 YVWGIVSWG-ENCGKPEFPGVYTRVANYFDWI 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	13/50 (26%)
		Tryp_SPc	131..388	CDD:214473	78/267 (29%)
		Tryp_SPc	133..391	CDD:238113	79/267 (30%)
Cfi	NP_031712.2	FIMAC	46..111	CDD:214493
		SR	117..220	CDD:214555
		SRCR	122..219	CDD:278931
		LDLa	232..261	CDD:238060	11/37 (30%)
		LDLa	264..298	CDD:294076	5/38 (13%)
		Tryp_SPc	360..589	CDD:214473	78/267 (29%)
		Tryp_SPc	361..592	CDD:238113	79/268 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910