DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and St14

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_446087.1	Gene:	St14 / 114093	RGDID:	69288	Length:	855	Species:	Rattus norvegicus

Alignment Length:	413	Identity:	119/413 - (28%)
Similarity:	174/413 - (42%)	Gaps:	102/413 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QFGKAIMHFGNCNSV-EFGRGTCIEKKDC--DFYAVDKLMELASKQQCFSR----QRPDLVCCPR 75
            ||.|.:  |..|:|| :.|.|:..|...|  ..:.......|...|||..:    ...|...|
  Rat   499 QFCKPL--FWVCDSVNDCGDGSDEEGCSCPAGSFKCSNGKCLPQSQQCNGKDDCGDGSDEASC-- 559

  Fly    76 ETNIIPPLAPRISNGTTNATSSTTTLKLLPRTTPRPPSGIDQLPEHPYC--------GS------ 126
                          ...||.|.|       :.|.|..:|:.....:|.|        ||
  Rat   560 --------------DNVNAVSCT-------KYTYRCQNGLCLNKGNPECDGKKDCSDGSDEKNCD 603

  Fly   127 ----AFS--FRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCI------ 179
                :|:  .|:|||.|....|:||...|.    :.|:.:.||||.|:..||::||||.
  Rat   604 CGLRSFTKQARVVGGTNADEGEWPWQVSLH----ALGQGHLCGASLISPDWLVSAAHCFQDETIF 664

  Fly   180 ----HTMGRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYRNDIA 240
                |||    ..|.||..::.     :...:||:|    |   .:.||:.|..:::..:..|||
  Rat   665 KYSDHTM----WTAFLGLLDQS-----KRSASGVQE----H---KLKRIITHPSFNDFTFDYDIA 713

  Fly   241 LLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGS-SKIKQKAMLHIQPQ 304
            ||.|.:|..:..:  :.|:|||.....:.   ||.|..|:|||.|:..|: :.|.||..:.:..|
  Rat   714 LLELEKPAEYSTV--VRPICLPDNTHVFP---AGKAIWVTGWGHTKEGGTGALILQKGEIRVINQ 773

  Fly   305 DQCQEAFYKDTKITLADSQMCAG---GEIGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGR 366
            ..|:|...:.    :....||.|   |  |||||.|||||||    ::...:..::.|||||.|
  Rat   774 TTCEELLPQQ----ITPRMMCVGFLSG--GVDSCQGDSGGPL----SSVEKDGRIFQAGVVSWG- 827

  Fly   367 KHCGTALFSGIYTRVSSYMDWIE 389
            :.|......|:|||:....|||:
  Rat   828 EGCAQRNKPGVYTRIPEVRDWIK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	12/51 (24%)
		Tryp_SPc	131..388	CDD:214473	88/270 (33%)
		Tryp_SPc	133..391	CDD:238113	89/271 (33%)
St14	NP_446087.1	SEA	88..178	CDD:396113
		CUB	214..332	CDD:238001
		CUB	340..444	CDD:238001
		LDLa	454..486	CDD:238060
		LDLa	492..523	CDD:238060	10/25 (40%)
		LDLa	525..559	CDD:238060	6/33 (18%)
		LDLa	567..602	CDD:238060	8/41 (20%)
		Tryp_SPc	615..852	CDD:238113	89/272 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910