DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and KLK11

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_011524671.1	Gene:	KLK11 / 11012	HGNCID:	6359	Length:	307	Species:	Homo sapiens

Alignment Length:	308	Identity:	86/308 - (27%)
Similarity:	133/308 - (43%)	Gaps:	81/308 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 AFSFRLVGGHNTGLFEF-------PWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHT--- 181
            |.:..||||....:..|       ||...|..:|     ...|||:.||.|||||||||:..
Human    42 ALATGLVGGETRIIKGFECKPHSQPWQAALFEKT-----RLLCGATLIAPRWLLTAAHCLKPWVS 101

  Fly   182 ------MGRNLTAA------------ILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHA 228
                  :..:|:::            .||:.|...:..||...             |.....||.
Human   102 LTSPTHVSPDLSSSNYCLSHLSRYIVHLGQHNLQKEEGCEQTR-------------TATESFPHP 153

  Fly   229 QYS----ELNYRNDIALLRLSRPVN--W-LQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTE 286
            .::    ..::||||.|::::.||:  | ::...|...|:          .||::..:||||.|
Human   154 GFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCV----------TAGTSCLISGWGST- 207

  Fly   287 SSGSSKIKQK---AMLHIQPQDQCQEAFYKDTKITLADSQMCAG-GEIGVDSCSGDSGGPLTVEA 347
            ||...::...   |.:.|....:|:.|:..:    :.|:.:||. .|.|.|||.|||||||....
Human   208 SSPQLRLPHTLRCANITIIEHQKCENAYPGN----ITDTMVCASVQEGGKDSCQGDSGGPLVCNQ 268

  Fly   348 NTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIESTIRAN 395
            :         |.|::|.|:..|......|:||:|..|:|||:.|::.|
Human   269 S---------LQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMKNN 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	81/295 (27%)
		Tryp_SPc	133..391	CDD:238113	82/296 (28%)
KLK11	XP_011524671.1	Tryp_SPc	53..300	CDD:214473	77/288 (27%)
KLK11	XP_011524671.1	Tryp_SPc	54..303	CDD:238113	79/290 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910