DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and MASP2

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens

Alignment Length:	288	Identity:	80/288 - (27%)
Similarity:	136/288 - (47%)	Gaps:	36/288 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 GIDQLPE-HPYCG-SAFSF--RLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLT 174
            |...||. .|.|| ||.:.  |:.||......:|||..|:...|.:.|       :.:...|:||
Human   423 GEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAG-------ALLYDNWVLT 480

  Fly   175 AAHCIHTMGRNLTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYS-ELNYRND 238
            |||.::....:.:|             .:..:..::..:|.:.:...:.:..|..|: :..:.||
Human   481 AAHAVYEQKHDASA-------------LDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDND 532

  Fly   239 IALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAMLHIQP 303
            |||::|:..|  :...|:.|:|||.:... :..........||||.|:....::......:.|..
Human   533 IALIKLNNKV--VINSNITPICLPRKEAE-SFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVD 594

  Fly   304 QDQCQEAFYKD--TKITLADSQMCAGGEI-GVDSCSGDSGGPLT-VEANTASGNRYVYLAGVVSI 364
            ..:|..|:.|.  .:.::..:.:|||.|. |.|||.|||||.|. :::.|   .|: ::.|:||.
Human   595 HQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSET---ERW-FVGGIVSW 655

  Fly   365 GRKHCGTALFSGIYTRVSSYMDWIESTI 392
            |..:||.|...|:||:|.:|:.|||:.|
Human   656 GSMNCGEAGQYGVYTKVINYIPWIENII 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	68/261 (26%)
		Tryp_SPc	133..391	CDD:238113	70/262 (27%)
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839
		CCP	300..361	CDD:214478
		Sushi	366..430	CDD:278512	3/6 (50%)
		Tryp_SPc	444..679	CDD:214473	68/261 (26%)
		Tryp_SPc	445..682	CDD:238113	70/263 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910