DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and CORIN

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_006578.2	Gene:	CORIN / 10699	HGNCID:	19012	Length:	1042	Species:	Homo sapiens

Alignment Length:	357	Identity:	97/357 - (27%)
Similarity:	141/357 - (39%)	Gaps:	111/357 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LASKQQCFSRQRPDLVC----CPRETNIIPPLAPRISNGTTNATSSTTTLKLLPRTTPRPPSGID 116
            |.:.|.|.||.:..|:|    |.|                                  ||.:.::
Human   769 LVNGQSCESRSKISLLCTKQDCGR----------------------------------RPAARMN 799

  Fly   117 QLPEHPYCGSAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHT 181
            :             |::||..:....:||...|:.|. ||   :.||...||::|:||.|||..
Human   800 K-------------RILGGRTSRPGRWPWQCSLQSEP-SG---HICGCVLIAKKWVLTVAHCFE- 846

  Fly   182 MGRNLTA---AILGEWNRDTDPDCENDLNGVRECAPPHIRV-----TIDRILPHAQYSELNYRND 238
             ||...|   .:||..|.|                  |..|     .:..|:.|.:||......|
Human   847 -GRENAAVWKVVLGINNLD------------------HPSVFMQTRFVKTIILHPRYSRAVVDYD 892

  Fly   239 IALLRLSRPVNWLQMQNLEPVCLP-------PQRGRYANQLAGSAADVSGWGKTESSGSSKIKQK 296
            |:::.||..::  :...:.|||||       |....|          ::|||...:....|: |:
Human   893 ISIVELSEDIS--ETGYVRPVCLPNPEQWLEPDTYCY----------ITGWGHMGNKMPFKL-QE 944

  Fly   297 AMLHIQPQDQCQEAFYKDTKITLADSQMCAGGEIG-VDSCSGDSGGPLTVEANTASGNRYVYLAG 360
            ..:.|...:.||.  |.|.| |:....:|||.|.| ||||.|||||||..|   ..|.|:. |.|
Human   945 GEVRIISLEHCQS--YFDMK-TITTRMICAGYESGTVDSCMGDSGGPLVCE---KPGGRWT-LFG 1002

  Fly   361 VVSIGRKHCGTALFSGIYTRVSSYMDWIESTI 392
            :.|.|.......|..|:|:.||.:::||:..|
Human  1003 LTSWGSVCFSKVLGPGVYSNVSYFVEWIKRQI 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	7/21 (33%)
		Tryp_SPc	131..388	CDD:214473	83/272 (31%)
		Tryp_SPc	133..391	CDD:238113	84/273 (31%)
CORIN	NP_006578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		DDNN motif	26..29
		CRD_corin_1	135..263	CDD:143554
		LDLa	269..304	CDD:238060
		LDLa	306..340	CDD:238060
		Ldl_recept_a	347..377	CDD:278486
		LDLa	387..414	CDD:238060
		CRD_corin_2	454..575	CDD:143579
		LDLa	580..614	CDD:238060
		LDLa	655..689	CDD:238060
		SR	690..786	CDD:214555	6/16 (38%)
		Tryp_SPc	801..1030	CDD:214473	83/272 (31%)
		Tryp_SPc	802..1033	CDD:238113	84/274 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910