DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and hgf

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_002933142.2	Gene:	hgf / 100495840	XenbaseID:	XB-GENE-999992	Length:	710	Species:	Xenopus tropicalis

Alignment Length:	408	Identity:	91/408 - (22%)
Similarity:	144/408 - (35%)	Gaps:	122/408 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GTCIEKKDCDFYAVDKLMELASKQQCF-----------SRQRPDLVCCPRETNIIPPLAPRISNG 90
            |.|.:...|         :.:::|:|:           ||.|..|.|...|.|:         ..
Frog   359 GHCSQIPKC---------QASNQQECYYGNGSTYKGTLSRTRFRLPCSMWEKNL---------QD 405

  Fly    91 TTNATSSTTTLKLLPRTTPRPPSGIDQLP----EHPY---------------------------C 124
            ....|.:...:.:|.:...|.|......|    :.|:                           |
Frog   406 LKRHTFNEPDVSILEKNYCRNPDNDAHGPWCYTDDPFVPWDYCHISRCEGDTTKIMANIDSPITC 470

  Fly   125 GSAFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLLTAAHCIHTMGRNLTAA 189
            .|:...|:|.|..|...:. |...:.|.     ..:.||.:.|.:.|:|||..|.
Frog   471 SSSKQLRVVNGIPTQTRKV-WMVSVRYR-----NSHKCGGTLIKENWVLTARQCF---------- 519

  Fly   190 ILGEWNRDTDPDCENDLNGVRECAPPH-IRVTIDRILPHAQYSELNY------RNDIALLRLSRP 247
            :.|          :|||.........| |..|.::   |.|...::.      .:::.||:||||
Frog   520 LSG----------DNDLKDYEAWLGVHNIYSTTEK---HKQVLNISQLVHGPKGSNLVLLKLSRP 571

  Fly   248 ------VNWLQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGSSKIKQKAMLHIQPQDQ 306
                  |:.:::.|..  |..|:         .:...|.|||.|.::......|:..|||...::
Frog   572 ATLNAYVDRIKLPNYG--CTIPE---------NTMCSVYGWGHTGTNDYDGQLQEGTLHIVGNEK 625

  Fly   307 CQEAFYKDTKITLADSQMCAGGE-IGVDSCSGDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCG 370
            |.|  :...|||:.:|::||..| ..:..|..|.||||..|.     ||...:.||:..|| .|.
Frog   626 CNE--HHKGKITVNESEICAMSETANIGPCERDYGGPLICEE-----NRTHLVQGVIIPGR-GCA 682

  Fly   371 TALFSGIYTRVSSYMDWI 388
            ......|:.||:.|..||
Frog   683 IQKRPVIFVRVAYYAKWI 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	10/47 (21%)
		Tryp_SPc	131..388	CDD:214473	69/270 (26%)
		Tryp_SPc	133..391	CDD:238113	70/270 (26%)
hgf	XP_002933142.2	PAN_AP_HGF	26..109	CDD:238532
		KR	113..195	CDD:214527
		KR	197..275	CDD:214527
		Kringle	289..367	CDD:333799	2/7 (29%)
		KR	373..454	CDD:238056	15/89 (17%)
		Tryp_SPc	478..703	CDD:238113	70/271 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910