DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and tmprss6

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	379	Identity:	107/379 - (28%)
Similarity:	162/379 - (42%)	Gaps:	82/379 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NCNSVEFGRGTCIEKKDCDFYAVDKLMELASKQQCFSRQRPDLVCCPRETNIIPPLAPRISNGTT 92
            :|.|:   ...|..||||                   ....|...|.:..|.     |..:.|..
Frog   491 SCISI---TSVCDGKKDC-------------------ANGTDEELCNQGANF-----PTAACGAF 528

  Fly    93 NATSSTTTLKLLPRTTPRPPSGIDQLPEHP------YCG---SAFSFRLVGGHNTGLFEFPWTTL 148
            |...:..:      ...:|.:..|.:.:.|      .||   .|...|||||......|:||...
Frog   529 NYKCADGS------CVQKPNAECDSIADCPDGSDENNCGCGIQAVGIRLVGGTQAQEGEWPWQAS 587

  Fly   149 LEYETVSGGKDYACGASFIAQRWLLTAAHCI---HTMGRNLTAAILGE--WNRDTDPDCENDLNG 208
            |:   |.|  ::.||.:.:|.:|:||||||.   ......:....||:  .:|.|.
Frog   588 LQ---VRG--EHICGGTLVADQWILTAAHCFTPESYASPEVWTVYLGKVRLSRSTQ--------- 638

  Fly   209 VRECAPPHIRVTIDRILPHAQYSELNYRNDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLA 273
             :|.|...||:.|     |..|.|.::..|:||:.|...|. |...:::|:|||.....:.   .
Frog   639 -KELAFKVIRLVI-----HPFYDEDSHDYDVALVLLDHLVP-LTSPHVQPICLPSSTHHFP---T 693

  Fly   274 GSAADVSGWGKTESSG-SSKIKQKAMLHIQPQDQCQEAFYKDTKITLADSQMCAGGEIG-VDSCS 336
            ||:..|:|||..:.:| :|.:.||..:.:..||.|.|.:    :..::...:|||...| .|:|.
Frog   694 GSSCWVTGWGSVKENGPTSDVLQKVDIQLVAQDICTELY----RYQISPRMLCAGYRDGSKDACQ 754

  Fly   337 GDSGGPLTVEANTASGNRYVYLAGVVSIGRKHCGTALFSGIYTRVSSYMDWIES 390
            ||||.||.  ..|||| |: :.||:||.| ..||...:.|:|:|::..:.||||
Frog   755 GDSGSPLV--CKTASG-RW-FQAGLVSWG-AGCGIPRYFGVYSRITRLVQWIES 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829	8/44 (18%)
		Tryp_SPc	131..388	CDD:214473	84/263 (32%)
		Tryp_SPc	133..391	CDD:238113	86/265 (32%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060	8/44 (18%)
		LDLa	525..560	CDD:238060	5/40 (13%)
		Tryp_SPc	572..804	CDD:238113	86/265 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910