DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser7 and tmprss12

DIOPT Version :9

Sequence 1:	NP_572582.1	Gene:	Ser7 / 31917	FlyBaseID:	FBgn0019929	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_031751504.1	Gene:	tmprss12 / 100127698	XenbaseID:	XB-GENE-964846	Length:	324	Species:	Xenopus tropicalis

Alignment Length:	286	Identity:	98/286 - (34%)
Similarity:	133/286 - (46%)	Gaps:	35/286 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 GIDQLPEHPYCGS-----AFSFRLVGGHNTGLFEFPWTTLLEYETVSGGKDYACGASFIAQRWLL 173
            ||.|..:...||.     ....|:|||.|.....:||...|:|.....|..:.||.|.|...|:|
Frog    18 GIIQAIDSEVCGEPPLVHTPGSRIVGGRNALPGAWPWQVSLQYFRTLSGYSHRCGGSLIQNNWVL 82

  Fly   174 TAAHCIHTMGRN--LTAAILGEWNRDTDPDCENDLNGVRECAPPHIRVTIDRILPHAQYSELNYR 236
            :||||... .||  ...|:||             |:.:.....|.::..|.:|:.||.|..:...
Frog    83 SAAHCFRA-NRNPEYWRAVLG-------------LHNIFMEGSPVVKAKIKQIIIHASYDHIAIT 133

  Fly   237 NDIALLRLSRPVNWLQMQNLEPVCLPPQRGRYANQLAGSAADVSGWGKTESSGS-SKIKQKAMLH 300
            ||||||.|...|.:  ...:.||||    |......:.:|..::|||.|:..|| |.|.|:|::.
Frog   134 NDIALLLLHDFVTY--SDYIHPVCL----GSVTVPDSLTACFITGWGVTKEKGSISVILQEALVQ 192

  Fly   301 IQPQDQCQEAFYKDTKITLADSQMCAGGEIG-VDSCSGDSGGPLTVEANTASGNRYVYLAGVVSI 364
            ..|..:|..:...:..||  .|.:|||...| ||||.||||||. |..||.  ....|..|:.|.
Frog   193 TIPYSECNSSSSYNGFIT--QSMICAGDNSGAVDSCQGDSGGPF-VCYNTE--RMRFYQMGITSF 252

  Fly   365 GRKHCGTALFSGIYTRVSSYMDWIES 390
            | ..||...|.|:||:|.||:.||::
Frog   253 G-YGCGKPNFPGVYTKVESYVSWIKA 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser7	NP_572582.1	CLIP	29..74	CDD:197829
		Tryp_SPc	131..388	CDD:214473	91/260 (35%)
		Tryp_SPc	133..391	CDD:238113	92/262 (35%)
tmprss12	XP_031751504.1	Tryp_SPc	41..278	CDD:238113	92/263 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910