DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CARPB and CA11

DIOPT Version :9

Sequence 1:	NP_001245593.1	Gene:	CARPB / 31915	FlyBaseID:	FBgn0052698	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	NP_001208.2	Gene:	CA11 / 770	HGNCID:	1370	Length:	328	Species:	Homo sapiens

Alignment Length:	282	Identity:	112/282 - (39%)
Similarity:	161/282 - (57%)	Gaps:	19/282 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EDWWTY------DGISGPAFWGLINPEWSLCNKGRRQSPVNLEPQRLLFDPNLRPMHIDK--HRI 83
            ||||:|      :.:.||.||||:|..||||..|:|||||::|.:|:|:||.|.|:.:..  .::
Human    32 EDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKL 96

  Fly    84 SGLITNTGHSVIFTAGNDTVANYDGMQTPVNISGGPLSYRYRFHEIHMHYGLNDQFGSEHSVEGY 148
            .|.:.|||..|.|......|         ||:|||||.|.:|..|:.:.:|..|..||||.:...
Human    97 RGTLYNTGRHVSFLPAPRPV---------VNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQ 152

  Fly   149 TFPAEIQIFGYNSQLYANFSDALNRAQGIVGVSILLQLGDLSNAEL-RMLT-DQLERIRYGGDEA 211
            .|.||:|:..:|.:||.|||.|.....|:..:|:.:.:...||..| |:|. |.:.||.|..|..
Human   153 GFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAY 217

  Fly   212 FVKRLSIRGLLPDTDHYMTYDGSTTAPACHETVTWVVLNKPIYITKQQLHALRRLMQGSPDHPKA 276
            |::.||:..|.|::..::||.||.:.|.|.|||||:::::.:.||..|:|:||.|.|..|.....
Human   218 FLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQ 282

  Fly   277 PLGNNYRPPQPLLHRPIRTNID 298
            .|..|.||.|||.||.:|.|.|
Human   283 SLSGNSRPLQPLAHRALRGNRD 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CARPB	NP_001245593.1	alpha_CARP_X_XI_like	37..298	CDD:239395	106/264 (40%)
CA11	NP_001208.2	alpha_CARP_X_XI_like	48..304	CDD:239395	106/264 (40%)
CA11	NP_001208.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..328		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145715
Domainoid	1	1.000	234	1.000	Domainoid score	I2391
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3255
Isobase	1	0.950	-	0	Normalized mean entropy	S4838
OMA	1	1.010	-	-		QHG45680
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0002299
OrthoInspector	1	1.000	-	-		mtm8599
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1354
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.860