DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CARPB and CA10

DIOPT Version :9

Sequence 1:	NP_001245593.1	Gene:	CARPB / 31915	FlyBaseID:	FBgn0052698	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	NP_001076002.1	Gene:	CA10 / 56934	HGNCID:	1369	Length:	328	Species:	Homo sapiens

Alignment Length:	331	Identity:	132/331 - (39%)
Similarity:	191/331 - (57%)	Gaps:	30/331 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLLARMQVLLAVS------WEDWWTY-DGISG-----PAFWGLINPEWSLCNKGRRQSPVNLE 63
            |.||.|...|.::..      .|.||.| :.:.|     |:||||:|..|:||:.|:||||||:|
Human     8 LFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNLCSVGKRQSPVNIE 72

  Fly    64 PQRLLFDPNLRPMHIDK--HRISGLITNTGHSVIFTAGNDTVANYDGMQTPVNISGGPLSYRYRF 126
            ...::|||.|.|:.|:.  .::||.:.|||..|......:.:         |||||||::|.:|.
Human    73 TSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHL---------VNISGGPMTYSHRL 128

  Fly   127 HEIHMHYGLNDQFGSEHSVEGYTFPAEIQIFGYNSQLYANFSDALNRAQGIVGVSILLQLGDLSN 191
            .||.:|:|..|..||||.:.|..|..|:|:..||.:||.|.::|.....|:|.|||.:::.|.||
Human   129 EEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSN 193

  Fly   192 AEL-RMLT-DQLERIRYGGDEAFVKRLSIRGLLPDTDHYMTYDGSTTAPACHETVTWVVLNKPIY 254
            ..| |||. |.:.||.|..|...::.|:|..|.|:|..::|||||.|.|.|:||.:|:::|||:|
Human   194 PFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVY 258

  Fly   255 ITKQQLHALRRLMQGSPDHPKAPLGNNYRPPQPLLHRPIRTNIDFKTTKSNGKAACP-TMYREVY 318
            ||:.|:|:||.|.|..|......:.:|:||.|||.:|.|||||:|..   .|| .|| ...:::.
Human   259 ITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSL---QGK-DCPNNRAQKLQ 319

  Fly   319 YKATSW 324
            |:...|
Human   320 YRVNEW 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CARPB	NP_001245593.1	alpha_CARP_X_XI_like	37..298	CDD:239395	115/269 (43%)
CA10	NP_001076002.1	alpha_CARP_X_XI_like	46..302	CDD:239395	114/264 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145773
Domainoid	1	1.000	234	1.000	Domainoid score	I2391
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23201
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3255
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45680
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0002299
OrthoInspector	1	1.000	-	-		mtm8599
orthoMCL	1	0.900	-	-		OOG6_106561
Panther	1	1.100	-	-	LDO	PTHR18952
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8915
SonicParanoid	1	1.000	-	-		X1354
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840