DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and SP6

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001245177.1	Gene:	SP6 / 80320	HGNCID:	14530	Length:	376	Species:	Homo sapiens

Alignment Length:	356	Identity:	140/356 - (39%)
Similarity:	181/356 - (50%)	Gaps:	88/356 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 VEAGAAAFGGVYSR-------HPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDM--------- 257
            :|:.:....|.:|:       |.|:..|.. ||..|.  :..|||:|... ||:|:
Human    81 LESDSPLAPGPFSKLLQPDMSHHYESWFRP-THPGAE--DGSWWDLHPGT-SWMDLPHTQGALTS 141

  Fly   258 -GGAG-MHSTMANYASENYSSA-----LSHSLL--GSGQHLLQDTYKSMLPGQGVGVGVGVGMGG 313
             |..| :.:.:..|..::...|     .:|.||  ..|||||                 |...|.
Human   142 PGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLL-----------------GPPDGA 189

  Fly   314 FSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLG-PAGV 377
            .:|..::|.:....::...||   .|:|...|.|      |.:|:..|.||||.|||||| |.|.
Human   190 KALEVAAPESQGLDSSLDGAA---RPKGSRRSVP------RSSGQTVCRCPNCLEAERLGAPCGP 245

  Fly   378 H-LRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTG 441
            . .:||::|:||||||||.|.||||||||||||:|:||||||||||||||||||||||||:||||
Human   246 DGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTG 310

  Fly   442 EKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGESNGL 506
            .|:|.|.||::.||||||||||:|||.|.                      .||||   |.::|.
Human   311 TKKFPCAVCSRVFMRSDHLAKHMKTHEGA----------------------KEEAA---GAASGE 350

  Fly   507 GGVGSGPQTGGAGGGGGGSSSGNGAGTLAVS 537
            |      :.|||....||.......|::|.|
Human   351 G------KAGGAVEPPGGKGKREAEGSVAPS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	16/18 (89%)
		zf-H2C2_2	401..428	CDD:290200	24/26 (92%)
		C2H2 Zn finger	417..439	CDD:275368	20/21 (95%)
		zf-H2C2_2	431..454	CDD:290200	15/22 (68%)
		zf-C2H2	445..467	CDD:278523	15/21 (71%)
		C2H2 Zn finger	447..467	CDD:275368	14/19 (74%)
SP6	NP_001245177.1	SP6_N	1..255	CDD:411693	55/203 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	118..126		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..223		19/81 (23%)
		C2H2 Zn finger	259..278	CDD:275368	16/18 (89%)
		COG5048	<261..>336	CDD:227381	61/74 (82%)
		C2H2 Zn finger	286..308	CDD:275368	20/21 (95%)
		C2H2 Zn finger	316..336	CDD:275368	14/19 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..376		19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010