Protein Alignment Sp1 and Sp2

DIOPT Version :10

• Sequence 1: NP_001259388.1
• Gene: Sp1 / 31913
• FlyBaseID: FBgn0020378
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_084496.2
• Gene: Sp2 / 78912
• MGIID: 1926162
• Length: 613
• Species: Mus musculus
• Alignment Length: 615
• Identity: 165/615 - (26%)
• Similarity: 221/615 - (35%)
• Gaps: 228/615 - (37%)

  Fly    46 TPLAMLAAQCNKLSNKSPPPLADAAV---------GKGFHPWKKS--PNSPAAGSSGSSGGGGG- 98
            :|||:|||.|:|:.    ||..:|||         .:...|.|.:  |.||...|.......|.
Mouse    34 SPLALLAATCSKIG----PPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPCKNSFSILSSKGNI 94

  Fly    99 -------------GGGSSAGQHSPCAISAASSSSSS-----GSSGGQSSRSL------------- 132
                         ||.......:|..|:..|.|::|     ....|.||:::
Mouse    95 LQIQGSQLSTSYPGGQFVFAIQNPTLINKGSRSNASIQYQVPQIQGNSSQTIQVQPSLTNQIQVI 159

  Fly   133 --SSSASTMVNITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSN 195
              ::.|.|..:.:..:|:....|.|...||.::...||      |:.|....||         ||
Mouse   160 PGTNQAITTPSTSGHKPVPIKPAPVQKSSTTTTPVQSG------ANVVKLTGGG---------SN 209

  Fly   196 MDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGA 260
            |........|:...:.|..|  .:.:..| ..|.:. |:|:|...:........|....::
Mouse   210 MTLTLPLNNLVNTSDIGGPA--QLLTESP-PTPLSK-TNKKARKKSLPVSQPSVAVAEQVE---- 266

  Fly   261 GMHSTMANYASENYSSALSHSLL----GSGQHLL-----------QDTYKSMLPGQGVGVGVGVG 310
               :.:....::|...|.::.|:    |.||..:           :......:|.|.:.|   |.
Mouse   267 ---TVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRV---VQ 325

  Fly   311 MGGFSLP------------------------------------HSSPSAAAA------------- 326
            ....:||                                    ..||.|.||
Mouse   326 AASATLPTVPQKPSQNFQIQTTEPTPTQVYIRTPSGEVQTVLVQDSPPATAATTSTVTCNSPALR 390

  Fly   327 -----------------------------------AAATAAAA---------------------- 334
                                               ||..||||
Mouse   391 APHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITN 455

  Fly   335 AGGSPQ--------------GGSPSTPSPRSQRRYAG---------RATCDCPNCQEAE-RLGPA 375
            .||..|              |.||:....:.::..||         |..|.||||::.| |.|..
Mouse   456 TGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGEAQPGEKRRRMACTCPNCKDGEKRSGEQ 520

  Fly   376 GVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHT 440
            |   :||  |.||||.|||.:.|||.|:||:|.|||||||||||.|||||||||||||||.||||
Mouse   521 G---KKK--HVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHT 580

  Fly   441 GEKRFACPVCNKRFMRSDHLAKHVKTHNGT 470
            |:|||.|..|.|||||||||.||.|||.||
Mouse   581 GDKRFECAQCQKRFMRSDHLTKHYKTHLGT 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	SP6-9-like_N	50..386	CDD:411694	95/525 (18%)
		C2H2 Zn finger	390..409	CDD:275368	11/18 (61%)
		zf-H2C2_2	401..428	CDD:463886	21/26 (81%)
		C2H2 Zn finger	417..439	CDD:275368	19/21 (90%)
		zf-H2C2_2	431..454	CDD:463886	16/22 (73%)
		zf-C2H2	445..467	CDD:395048	15/21 (71%)
		C2H2 Zn finger	447..467	CDD:275368	14/19 (74%)
Sp2	NP_084496.2	SP2_N	10..526	CDD:411776	98/529 (19%)
		C2H2 Zn finger	530..549	CDD:275368	11/18 (61%)
		zf-H2C2_2	542..568	CDD:463886	21/25 (84%)
		C2H2 Zn finger	557..579	CDD:275368	19/21 (90%)
		zf-H2C2_2	571..594	CDD:463886	16/22 (73%)
		zf-C2H2	585..607	CDD:395048	15/21 (71%)
		C2H2 Zn finger	587..607	CDD:275368	14/19 (74%)