DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and SP3

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_003102.1	Gene:	SP3 / 6670	HGNCID:	11208	Length:	781	Species:	Homo sapiens

Alignment Length:	766	Identity:	196/766 - (25%)
Similarity:	261/766 - (34%)	Gaps:	317/766 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TPLAMLAAQCNKLSNKSPPPLADAAVGKGFHPWKKSPNSPAAGSSGSSGGGGGGGGSSAGQ---H 107
            :|||:|||.|:|:...||....:.|......|       .|||::|.......||..:..:   .
Human    57 SPLALLAATCSKIGPPSPGDDEEEAAAAAGAP-------AAAGATGDLASAQLGGAPNRWEVLSA 114

  Fly   108 SPCAI-----------SAASSSSS--------------SGSSGGQSSRSLSSSASTMVNITASRP 147
            :|..|           |||:||..              |.:.|..||....||....|     .|
Human   115 TPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQV-----IP 174

  Fly   148 LASSC--AAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLL---G 207
            ...|.  ..|..|.||||.:...:|.||....:..: ...|....|.::|:.|      |:   |
Human   175 QIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGS-NQTLLASGTPSANIQN------LIPQTG 232

  Fly   208 KVEAGAAAFGG--------VYSRHPYDWPFN------------------------AVTHKEAASV 240
            :|:....|.||        |.:..|...|.|                        |..:.:...:
Human   233 QVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLI 297

  Fly   241 NSGWWDMHSAAGS--------------------------------WLDMGG-------------A 260
            |:| ..|.|:..|                                .:|..|             .
Human   298 NTG-QAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSG 361

  Fly   261 GMHST--MANYASENYSSALS---------------------------------------HSLLG 284
            .:||:  ..||.....|....                                       |.:..
Human   362 QVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQA 426

  Fly   285 SGQHL----LQDTYKSMLPG----------------------QGV-------------------- 303
            |||::    ||:....:.||                      |||
Human   427 SGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTP 491

  Fly   304 ----GVGVGVGMGGFSLPHSSPSAAA--------AAAATAAAAAGGSPQGG----SPS------- 345
                .:|.....|.|:   |:|.:.:        .....:..:||.....|    ||:
Human   492 VQTLTLGQVAAGGAFT---STPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEE 553

  Fly   346 TPSPR---------------------------SQRRYAG----RATCDCPNCQEAERLGPAGVHL 379
            .|.|.                           .|:...|    |..|.||||:|.   |..|.:|
Human   554 EPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEG---GGRGTNL 615

  Fly   380 RKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKR 444
            .||..|.||||||||||||||||:||||||:|||||||||::||||||||||||||.|||||||:
Human   616 GKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKK 680

  Fly   445 FACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKG--SSESCSDSEEAANQSGESNGLG 507
            |.||.|:||||||||||||:|||..             |||  ||.:...|.|||..
Human   681 FVCPECSKRFMRSDHLAKHIKTHQN-------------KKGIHSSSTVLASVEAARD-------- 724

  Fly   508 GVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSGTGSSNSNSN 558
                             .:.....||..:..::..|:.:|.||.::::.||
Human   725 -----------------DTLITAGGTTLILANIQQGSVSGIGTVNTSATSN 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	17/18 (94%)
		zf-H2C2_2	401..428	CDD:290200	22/26 (85%)
		C2H2 Zn finger	417..439	CDD:275368	18/21 (86%)
		zf-H2C2_2	431..454	CDD:290200	17/22 (77%)
		zf-C2H2	445..467	CDD:278523	17/21 (81%)
		C2H2 Zn finger	447..467	CDD:275368	16/19 (84%)
SP3	NP_003102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..88		5/22 (23%)
		Transactivation domain (Gln-rich)	138..237		25/110 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338		3/36 (8%)
		Transactivation domain (Gln-rich)	350..499		16/148 (11%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	461..469		0/7 (0%)
		Repressor domain	534..620		19/88 (22%)
		C2H2 Zn finger	623..645	CDD:275368	20/21 (95%)
		COG5048	<636..718	CDD:227381	63/94 (67%)
		zf-H2C2_2	637..664	CDD:290200	22/26 (85%)
		C2H2 Zn finger	653..675	CDD:275368	18/21 (86%)
		zf-H2C2_2	667..690	CDD:290200	17/22 (77%)
		zf-C2H2	681..703	CDD:278523	17/21 (81%)
		C2H2 Zn finger	683..703	CDD:275368	16/19 (84%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010