DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sp1 and SP1

DIOPT Version :9

Sequence 1:NP_001259388.1 Gene:Sp1 / 31913 FlyBaseID:FBgn0020378 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_612482.2 Gene:SP1 / 6667 HGNCID:11205 Length:785 Species:Homo sapiens


Alignment Length:786 Identity:204/786 - (25%)
Similarity:275/786 - (34%) Gaps:317/786 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 TPLAMLAAQCNKL------SNKSPPPLADAAVG----------KGFHPWKKSPNSPAA-----GS 89
            :|||:|||.|:::      ||.|..|......|          :|.:.|:...:|..|     ..
Human    59 SPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQ 123

  Fly    90 SGSSGGGGGGGGS------SAGQH----SP----------------------------------- 109
            ||||..|..|..|      |.||:    :|                                   
Human   124 SGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQ 188

  Fly   110 -CAISAASSSSSSG----------------SSGG----------QSSRSLSSSASTM-------- 139
             .|..|......||                .|||          |.:..|...|:.:        
Human   189 FAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYV 253

  Fly   140 ---------------VNITASRPLASSCAAVGGGSTGSSSSASGSQSS----STASAVAAAYGGD 185
                           ||..::..|..|..||...|:||..|.|...:|    |:||.|::.....
Human   254 TNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSS 318

  Fly   186 LYFPN-------TSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSG 243
            .:|.|       |:||||       |::....:|::   |..|:.......:.:...:|.::...
Human   319 SFFTNANSYSTTTTTSNM-------GIMNFTTSGSS---GTNSQGQTPQRVSGLQGSDALNIQQN 373

  Fly   244 WWDMHSAAGS------------------------WLDMGGAGMHSTM-ANYASENYSS-ALSHSL 282
                .::.||                        .|..||..:.:.. |..:.:.::: |:|...
Human   374 ----QTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQET 434

  Fly   283 L---------GSGQHLL--------------------------QDTYKSMLPGQGVGVGVGVGMG 312
            |         .||..::                          |....::.|.|||.:|......
Human   435 LQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSN 499

  Fly   313 GFSLPHSSPSAAAAAAATAAAA------------------------------------------- 334
            ....|.:|.::..|...|..||                                           
Human   500 TTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQ 564

  Fly   335 -----AGG-----SPQGGSPSTPSPRSQRRYAGRAT----CDCPNCQEAERLG---PAGVHLRKK 382
                 |||     ...||.....||.:|.: |||.|    |.||.|:::|..|   |.     ||
Human   565 LGLHGAGGDGIHDDTAGGEEGENSPDAQPQ-AGRRTRREACTCPYCKDSEGRGSGDPG-----KK 623

  Fly   383 NIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFAC 447
            ..|.|||.||||||||||||:||||||||||||:|.|.:||||||||||||||.|||||||:|||
Human   624 KQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKKFAC 688

  Fly   448 PVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGESNGLG---GV 509
            |.|.|||||||||:||:|||..             |||                   |.|   .|
Human   689 PECPKRFMRSDHLSKHIKTHQN-------------KKG-------------------GPGVALSV 721

  Fly   510 GSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSG------TGSSNSNSNSGGSSGSVSG 568
            |:.|...|||        ..|:||...|..:||...|...      ...:||..|....:...|.
Human   722 GTLPLDSGAG--------SEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSI 778

  Fly   569 SVSGSG 574
            ::||:|
Human   779 NISGNG 784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sp1NP_001259388.1 C2H2 Zn finger 390..409 CDD:275368 16/18 (89%)
zf-H2C2_2 401..428 CDD:290200 21/26 (81%)
C2H2 Zn finger 417..439 CDD:275368 17/21 (81%)
zf-H2C2_2 431..454 CDD:290200 18/22 (82%)
zf-C2H2 445..467 CDD:278523 17/21 (81%)
C2H2 Zn finger 447..467 CDD:275368 15/19 (79%)
SP1NP_612482.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..93 12/33 (36%)
Repressor domain 2..82 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..141 9/31 (29%)
Transactivation domain A (Gln-rich) 146..251 12/104 (12%)
Transactivation domain B (Gln-rich) 261..495 45/247 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 329..395 12/79 (15%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 462..470 0/7 (0%)
Transactivation domain C (highly charged) 496..610 21/114 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 567..598 10/31 (32%)
VZV IE62-binding 619..785 98/211 (46%)
C2H2 Zn finger 628..650 CDD:275368 19/21 (90%)
zf-H2C2_2 642..669 CDD:290200 21/26 (81%)
C2H2 Zn finger 658..680 CDD:275368 17/21 (81%)
zf-H2C2_2 672..695 CDD:290200 18/22 (82%)
zf-C2H2 686..708 CDD:278523 17/21 (81%)
C2H2 Zn finger 688..708 CDD:275368 15/19 (79%)
Domain D 708..785 26/117 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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