DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and sp2

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001093452.2	Gene:	sp2 / 556835	ZFINID:	ZDB-GENE-080410-1	Length:	610	Species:	Danio rerio

Alignment Length:	635	Identity:	169/635 - (26%)
Similarity:	227/635 - (35%)	Gaps:	211/635 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QIPAMGMNISNIATHLQKPQVNPDHPSLRGTPLAMLAAQCNKLSNKSPPPLADAAVG-------- 72
            |..:|...::...:...:|.......| :.:|||:|||.|:|:.    ||.|.|.|.
Zfish     4 QKDSMATTVAVSPSEYLQPSTTTSQDS-QPSPLALLAATCSKIG----PPAAQAPVSTPPSQPTT 63

  Fly    73 KGFHPWKKSPNSPA----AGSSGSSGG----GGGGGGSSAGQHSPCAISAASSSSSSGSS----- 124
            :..||.|.:|.:||    .|...:.|.    ..|.|.|.|   ||...:..|.|..:|:|
Zfish    64 RRLHPIKPAPIAPAPPKNLGFLSAKGNIIQLPAGLGSSGA---SPIVFTFQSPSRPAGTSTANFQ 125

  Fly   125 ------------------GGQ-------------------------------------------- 127
                              |||
Zfish   126 YQVIPQFQGSQTIQMMPQGGQIQIIPGTNQAIITSPVTVQAATPTAPPLAPAPVPQHKTVAIKPS 190

  Fly   128 SSRSLSSSASTMVNIT-----ASRPLASSCAAVGGGSTGSSSSAS-------------------G 168
            :.:...::||...||.     .:.||..:...|||....:.::|:                   .
Zfish   191 TQKRRQNNASVNANIVRLPSGLTLPLNVTTGDVGGAQVLTETAAAPVKPKRGRKRQVAIAAPAPA 255

  Fly   169 SQSSS---------------TASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGK---------- 208
            .|.:|               ||..:..|....|...|...|........|.|..|
Zfish   256 PQPASPPPVAEQVEALLIETTADNIIQAGNNLLIVQNPGGSQPAVVQQVQLLQQKSDQQVVQIPP 320

  Fly   209 -----VEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMAN 268
                 |:|.:|....|..|.... |...|:..|...|.     :.:|:|.|..:.......|...
Zfish   321 QALKVVQAASATLPPVPQRQTVT-PSVQVSPPEPTQVL-----IKTASGEWQAVQIQETTVTTPT 379

  Fly   269 YASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAAT--- 330
            ..:...:.|:....:.:|.. .:.|...:.|..|         |..:|..:..::||.|..|
Zfish   380 TPTSTPTPAVVTKKVQTGTR-KERTLPKIAPAGG---------GLITLNAAQLASAAQAVQTINI 434

  Fly   331 ----------AAAAAGGSP------------QGGSPSTPS------------------PRSQRRY 355
                      ....|||..            |.||..|.:                  |..::|
Zfish   435 NGVQVQGVPVTITNAGGQQHLTVQTVPSAGLQLGSVQTQTQTMQIEQTQTLALELQTQPGEKKR- 498

  Fly   356 AGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWL 420
              |..|.||||::||: .|..|..||   |.|||.||.|.:.|||.|:||:|.|||||||||||:
Zfish   499 --RMACTCPNCKDAEK-KPGEVGKRK---HICHIAGCEKTFRKTSLLRAHVRLHTGERPFVCNWV 557

  Fly   421 FCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGT 470
            |||||||||||||||.|||||:|||.|..|.|||||||||.||.|||..|
Zfish   558 FCGKRFTRSDELQRHARTHTGDKRFECNKCQKRFMRSDHLTKHYKTHINT 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	10/18 (56%)
		zf-H2C2_2	401..428	CDD:290200	21/26 (81%)
		C2H2 Zn finger	417..439	CDD:275368	19/21 (90%)
		zf-H2C2_2	431..454	CDD:290200	16/22 (73%)
		zf-C2H2	445..467	CDD:278523	15/21 (71%)
		C2H2 Zn finger	447..467	CDD:275368	14/19 (74%)
sp2	NP_001093452.2	C2H2 Zn finger	524..546	CDD:275368	13/21 (62%)
		COG5048	<529..>584	CDD:227381	43/54 (80%)
		zf-H2C2_2	539..565	CDD:290200	21/25 (84%)
		C2H2 Zn finger	554..576	CDD:275368	19/21 (90%)
		zf-H2C2_2	568..591	CDD:290200	16/22 (73%)
		zf-C2H2	582..604	CDD:278523	15/21 (71%)
		C2H2 Zn finger	584..604	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010