DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and Spps

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	616	Identity:	171/616 - (27%)
Similarity:	234/616 - (37%)	Gaps:	228/616 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PTAGQ---LYGSQIPA-MGMNISNIATHL--QKPQVN---------PDHPSLRGTPLAMLAAQCN 56
            |..||   ::.:|:|. :..|...:.|.|  ..|||.         ...|.   :|..|:.
  Fly   493 PGLGQVQIIHANQLPPNLPANFQQVLTQLPMSHPQVQTQGQVQVMPKQEPQ---SPTQMIT---- 550

  Fly    57 KLSNKSPPPLADAAVGKGFHPWKKSPNSPAAGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSSS 121
              |.|..||       ..|.|...:.|.||..|:.::        :|..|.....:...|:|.||
  Fly   551 --SIKQEPP-------DTFGPISATGNPPAPASTPNT--------ASPQQQQIKFLHTESNSLSS 598

  Fly   122 GSSGG--------QSSRSLSSSASTMVNITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAV 178
            .|...        |.:.:..::.:|...|..|.|..|...||...||..:.:.:|.|   ..|..
  Fly   599 LSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITIAPTGGQ---VVSVT 660

  Fly   179 AAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSG 243
            ..|.|......:|:||.                                  ..:|....:.:|
  Fly   661 TQARGATASIRSTNTST----------------------------------TTITTPSQSHLN-- 689

  Fly   244 WWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVG 308
                              |:.::|:
  Fly   690 ------------------MNISVAS---------------------------------------- 696

  Fly   309 VGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLG 373
              :||                   ||.||   ||..:|..|:.:.:   |..|.||||.:.|:
  Fly   697 --VGG-------------------AATGG---GGGTATGEPKPRLK---RVACTCPNCTDGEK-- 732

  Fly   374 PAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRT 438
                |..||..|.|||.||.|||||||||:||||||||||||||:|.|||||||||||||||.||
  Fly   733 ----HSDKKRQHICHITGCHKVYGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRT 793

  Fly   439 HTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGES 503
            |||||||.|..|||:|||||||:||:|||                 ..|.|..:..|.:.:. |:
  Fly   794 HTGEKRFQCQECNKKFMRSDHLSKHIKTH-----------------FKSRSGVELIELSIKQ-ET 840

  Fly   504 NGLGGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSGTGSSNSNSNSGGSSGSVSG 568
            .|    |:.|::         .|:.||..|:.:.|    |..|.:|:|:|           ||:.
  Fly   841 KG----GNAPKS---------ISTVNGIVTIEIPG----GGSAAAGSGAS-----------SVAA 877

  Fly   569 SVSGSGSHPGTPTSLHAHSANGTSSSLLGGG 599
            :|:||...||..|.:...:...:     |||
  Fly   878 TVAGSTVTPGGATIVQLPTVEAS-----GGG 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	15/18 (83%)
		zf-H2C2_2	401..428	CDD:290200	23/26 (88%)
		C2H2 Zn finger	417..439	CDD:275368	18/21 (86%)
		zf-H2C2_2	431..454	CDD:290200	18/22 (82%)
		zf-C2H2	445..467	CDD:278523	15/21 (71%)
		C2H2 Zn finger	447..467	CDD:275368	14/19 (74%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	78/124 (63%)
		C2H2 Zn finger	742..764	CDD:275368	18/21 (86%)
		zf-H2C2_2	756..783	CDD:290200	23/26 (88%)
		C2H2 Zn finger	772..794	CDD:275368	18/21 (86%)
		zf-H2C2_2	786..809	CDD:290200	18/22 (82%)
		zf-C2H2	800..822	CDD:278523	15/21 (71%)
		C2H2 Zn finger	802..822	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I7927
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14801
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010