DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and sp5

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_989092.1	Gene:	sp5 / 394696	XenbaseID:	XB-GENE-1217606	Length:	374	Species:	Xenopus tropicalis

Alignment Length:	454	Identity:	155/454 - (34%)
Similarity:	194/454 - (42%)	Gaps:	140/454 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PQVNPD---HPSLRGTPLAMLAAQCNKLSNKSPPPL------ADAAVG---KGFHPWKKSPNSPA 86
            |..:||   |     :|||:|||.|:::......|.      .|..:|   :.||||   .|..:
Frog    21 PSASPDVGKH-----SPLALLAATCSRIGQPGTGPADFIQFPYDPTIGSPSRIFHPW---TNEIS 77

  Fly    87 AGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSSSGSSGGQSS-------RSLSSSASTMVNITA 144
            |.|||......|.|              .|:|.:..:|..|||       .:..:..|...:.:.
Frog    78 AHSSGGIQPHNGIG--------------LSTSKTQLASHIQSSFVTHELPLTPPADPSYPYDYSP 128

  Fly   145 SRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKV 209
            .:.|....||.   .||..|....:...:..:.:.:|..|  :.|  |.||:.:....|
Frog   129 MKMLPPPMAAF---QTGCQSPYVPAVPYAPPAPITSALHG--FVP--SHSNLIHQQPRQ------ 180

  Fly   210 EAGAAAFGGVYSRHP-YDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMANYASEN 273
                      .|.:| .|.|               ||.:..|             :.:|
Frog   181 ----------LSPNPAEDMP---------------WWSIQQA-------------TPVA------ 201

  Fly   274 YSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGS 338
            ::|.:.|      .|......:|::.|                 ||.    .|...|..||.
Frog   202 HASTIPH------PHHRFPIQRSLVLG-----------------HSD----FAQYQTQIAAL--- 236

  Fly   339 PQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLK 403
                 ..|.||.:..|...|  |.|||||.:.....||    ||..|.|||||||||||||||||
Frog   237 -----LQTKSPLATARRCRR--CRCPNCQTSSGPDEAG----KKKQHICHIPGCGKVYGKTSHLK 290

  Fly   404 AHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTH 467
            ||||||:|||||:||||||||.||||||||||||||||||||.||.|.||||||||||||||||
Frog   291 AHLRWHSGERPFICNWLFCGKSFTRSDELQRHLRTHTGEKRFVCPECGKRFMRSDHLAKHVKTH 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	18/18 (100%)
		zf-H2C2_2	401..428	CDD:290200	23/26 (88%)
		C2H2 Zn finger	417..439	CDD:275368	20/21 (95%)
		zf-H2C2_2	431..454	CDD:290200	19/22 (86%)
		zf-C2H2	445..467	CDD:278523	18/21 (86%)
		C2H2 Zn finger	447..467	CDD:275368	17/19 (89%)
sp5	NP_989092.1	C2H2 Zn finger	277..296	CDD:275368	18/18 (100%)
		zf-C2H2	302..326	CDD:333835	21/23 (91%)
		C2H2 Zn finger	304..326	CDD:275368	20/21 (95%)
		zf-H2C2_2	318..341	CDD:372612	19/22 (86%)
		zf-C2H2	332..354	CDD:333835	18/21 (86%)
		C2H2 Zn finger	334..354	CDD:275368	17/19 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010