Protein Alignment Sp1 and SP5

DIOPT Version :9

• Sequence 1: NP_001259388.1
• Gene: Sp1 / 31913
• FlyBaseID: FBgn0020378
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: XP_011509461.1
• Gene: SP5 / 389058
• HGNCID: 14529
• Length: 454
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 169/507 - (33%)
• Similarity: 202/507 - (39%)
• Gaps: 191/507 - (37%)

  Fly    34 PQVNPD---HPSLRGTPLAMLAAQCNKLSN---KSPPPLA----DAAVG---KGFHPWKKSPNSP 85
            |..:||   |     :|||:|||.|:::..   .:||...    |.|:|   :.||||  :.:.|
Human    77 PSASPDLGKH-----SPLALLAATCSRIGQPGAAAPPDFLQVPYDPALGSPSRLFHPW--TADMP 134

  Fly    86 AAGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSS--------SGSSGGQSSRSLSSSA--STMV 140
            |                    |||.|:.....|..        ..|.|......|:..|  |...
Human   135 A--------------------HSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPY 179

  Fly   141 NITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDL--------------YFPNT 191
            ..:..:.|.||.||:      .:|.|......:..:|:...|...|              ..||.
Human   180 EFSPVKMLPSSMAAL------PASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNP 238

  Fly   192 STSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLD 256
            :                               |.|.|               ||.:..|
Human   239 A-------------------------------PDDLP---------------WWSIPQA------ 251

  Fly   257 MGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSS- 320
              |||..:                               |.:||.|:. |...|     .||:.
Human   252 --GAGPGA-------------------------------SGVPGSGLS-GACAG-----APHAPR 277

  Fly   321 -PSAAAAAAATAAAAAGGSPQGGS-----------------PSTPSPRSQRRYAGRATCDCPNCQ 367
             |::||||||.|||...|...|.|                 |...:.|..||      |.|||||
Human   278 FPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRR------CRCPNCQ 336

  Fly   368 EAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDEL 432
            .|.  |.......||..|.||:|||||||||||||||||||||||||||||||||||.|||||||
Human   337 AAG--GAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDEL 399

  Fly   433 QRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKK 484
            ||||||||||||||||.|.||||||||||||||||.   |.:......|:|:
Human   400 QRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQ---NKKLKVAEAGVKR 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	18/18 (100%)
		zf-H2C2_2	401..428	CDD:290200	25/26 (96%)
		C2H2 Zn finger	417..439	CDD:275368	20/21 (95%)
		zf-H2C2_2	431..454	CDD:290200	20/22 (91%)
		zf-C2H2	445..467	CDD:278523	19/21 (90%)
		C2H2 Zn finger	447..467	CDD:275368	17/19 (89%)
SP5	XP_011509461.1	C2H2 Zn finger	357..376	CDD:275368	18/18 (100%)
		COG5048	<367..440	CDD:227381	66/75 (88%)
		zf-H2C2_2	368..395	CDD:290200	25/26 (96%)
		C2H2 Zn finger	384..406	CDD:275368	20/21 (95%)
		zf-H2C2_2	398..421	CDD:290200	20/22 (91%)
		zf-C2H2	412..434	CDD:278523	19/21 (90%)
		C2H2 Zn finger	414..434	CDD:275368	17/19 (89%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010