DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and sp4

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_956418.1	Gene:	sp4 / 387291	ZFINID:	ZDB-GENE-031202-3	Length:	714	Species:	Danio rerio

Alignment Length:	671	Identity:	183/671 - (27%)
Similarity:	244/671 - (36%)	Gaps:	242/671 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TPLAMLAAQCNKLSNKSPPPLADA----------------------------AVGKGFHPWKKSP 82
            :|||:|||.|:|:........|.|                            ..|.|   |:...
Zfish    36 SPLALLAATCSKIGGVGAEGQAAAQQQIIIDPNQGLLQLQNPTQQLELVPAQLTGNG---WQIIA 97

  Fly    83 NSPA---------AGSSGSSGGGGGG------GGSSAGQHSPCAISAASSSSSSGS--------- 123
            .|||         ||::.:|.....|      |.::|.|.....|...:..:|||.
Zfish    98 TSPATATKDSIQQAGANAASSEAAAGRKVKAVGSNNAAQQQFQIIQVQNLPNSSGGIQYQVIPHL 162

  Fly   124 ----------------------------SGGQSSRSLSS-----SASTMVN-------------- 141
                                        |.|.:...|::     |||.:.|
Zfish   163 QTADGQQIQISPSNPAALSVQPEQIQLISTGNNQAILATPQRTGSASIVQNQTIPLQIRPSFPLQ 227

  Fly   142 ---------------------ITASRPLASSCAAVGGG--------------------------- 158
                                 :|.:.|:.::.|..||.
Zfish   228 LQTIQGTQAPMVTTLPINLGGVTLALPVINNVAGAGGSVQLLQSSDGSISNGNQLITTVTTSTAD 292

  Fly   159 STGSSSS---ASGSQS--------SSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQG------LL 206
            |||||:|   |:||.|        .||.|.|:|....|.....|.::.:.:.....|      ::
Zfish   293 STGSSTSTTTATGSDSVVVTSADGLSTTSMVSAESPKDNEADLTQSNGLQSTSEQAGQIQQFQIV 357

  Fly   207 G---------------------KVEAGAA-----------AF---GGVYSRHPYDWPFNAVTHKE 236
            |                     :::.|..           ||   ..|..|.|...|...::.:.
Zfish   358 GHPVLQQIQIQSPQQQVVQGSIQIQPGQTLQPVQQNLQLQAFQNPAQVLIRTPTLTPSGQISWQT 422

  Fly   237 AASVNSGWWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLL--GSGQHLLQDTYKSMLP 299
            ....|:|.....:.|......|| |..:.:|..........||.:.|  |||   :|....:.|.
Zfish   423 VQVQNAGMPQQLTLAPVASSAGG-GTFAQIAPLTLGGSPITLSAAQLPAGSG---VQTVNIAGLG 483

  Fly   300 GQGVGV-GVGVGMGGFSLPHSSPSAAAAAAATAAAAAGG-----SP-QGGSPSTPS-----PRSQ 352
            ..||.| ||.:.:.|..............:|......|.     || |.|...:||     |..:
Zfish   484 AAGVQVQGVPLTITGVQGQQQGQDGVKVQSAPVTVTVGNISNAVSPEQMGQVQSPSDQEGQPSKR 548

  Fly   353 RRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVC 417
            .|   |..|.||||::.|  |.......||..|.||:.||||||||||||:||||||||||||||
Zfish   549 LR---RVACSCPNCRDGE--GRNNSDPSKKKQHVCHMEGCGKVYGKTSHLRAHLRWHTGERPFVC 608

  Fly   418 NWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGL 482
            ||:|||||||||||||||.|||||||||.||.|:|||||||||:||:|||..
Zfish   609 NWIFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHIKTHQN------------- 660

  Fly   483 KKGSSE----SCSDSEEAANQ 499
            |||.:.    :..:.||..::
Zfish   661 KKGGAALTIITTDEMEEEVDE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	16/18 (89%)
		zf-H2C2_2	401..428	CDD:290200	24/26 (92%)
		C2H2 Zn finger	417..439	CDD:275368	19/21 (90%)
		zf-H2C2_2	431..454	CDD:290200	18/22 (82%)
		zf-C2H2	445..467	CDD:278523	16/21 (76%)
		C2H2 Zn finger	447..467	CDD:275368	15/19 (79%)
sp4	NP_956418.1	COG5048	<566..656	CDD:227381	71/89 (80%)
		C2H2 Zn finger	578..600	CDD:275368	18/21 (86%)
		zf-H2C2_2	592..619	CDD:290200	24/26 (92%)
		C2H2 Zn finger	608..630	CDD:275368	19/21 (90%)
		zf-H2C2_2	622..645	CDD:290200	18/22 (82%)
		zf-C2H2	636..658	CDD:278523	16/21 (76%)
		C2H2 Zn finger	638..658	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010