DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and sp8a

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_998406.2	Gene:	sp8a / 321264	ZFINID:	ZDB-GENE-030131-9849	Length:	406	Species:	Danio rerio

Alignment Length:	513	Identity:	214/513 - (41%)
Similarity:	264/513 - (51%)	Gaps:	159/513 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DHPSLRGTPLAMLAAQCNKLSNKSPPPLADA-AVGK-GFHPWKKSPNSPAAGSSGSSGGGGGGGG 101
            :.|.:..||||||||.|||:.:.|||  :|: :.|| ||||||:
Zfish     8 EEPRVGSTPLAMLAATCNKIGSSSPP--SDSGSFGKGGFHPWKR--------------------- 49

  Fly   102 SSAGQHSPCAISAASSSSSSGSSGGQSSRSLSSSASTMVNITASRPLASSCAAVGGGSTGSSSSA 166
                        ||.||.|....|.|.:.|.|:::|..:                   ||:::|.
Zfish    50 ------------AAPSSCSLSPFGAQRNDSFSANSSFSL-------------------TGTTTST 83

  Fly   167 SGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGL-LGKVEAGAAAFGGVYSR----HPYD 226
            |             .:|.|.....||.:|.......|.: :.||:    :..|:|.|    |||:
Zfish    84 S-------------PFGNDYPVFQTSVANSSQDPSAQSVFISKVD----SLQGIYPRMSVAHPYE 131

  Fly   227 WPFNAVTHKEAASVNSG------WWDMHSAAGSWLDMGGA-------GMHSTMANYASENYSSAL 278
            ..|.: .|   |.::||      |||:.:   .|:|:..|       .:||.::.|.|: |.| |
Zfish   132 TWFKS-AH---AGISSGDGSGSSWWDVGT---GWIDVQSANGAALQTSLHSPLSGYNSD-YPS-L 187

  Fly   279 SHS---------LLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAA 334
            :||         ||.|||||: |.:|.:|                          :|....::..
Zfish   188 THSAFSASPSPHLLSSGQHLM-DGFKPVL--------------------------SATYTDSSTG 225

  Fly   335 AGGSPQGGSPSTP---SPRSQ-RRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKV 395
            |..:..||||..|   ||||. |||:||||||||||||||||||||..||:|.:|||||||||||
Zfish   226 ANSAVLGGSPVVPLAGSPRSSTRRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKV 290

  Fly   396 YGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHL 460
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
Zfish   291 YGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFSCPVCNKRFMRSDHL 355

  Fly   461 AKHVKTHNGTANHQANGHNG--GLKKGS----------SESCSDSEEAANQSGESNGL 506
            :||||||:.       |..|  ||||.|          |.:|...|...|.....|||
Zfish   356 SKHVKTHSA-------GEPGSNGLKKSSDTDSEQSVPGSPACQSPEMIHNTEPVQNGL 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	18/18 (100%)
		zf-H2C2_2	401..428	CDD:290200	26/26 (100%)
		C2H2 Zn finger	417..439	CDD:275368	21/21 (100%)
		zf-H2C2_2	431..454	CDD:290200	21/22 (95%)
		zf-C2H2	445..467	CDD:278523	19/21 (90%)
		C2H2 Zn finger	447..467	CDD:275368	18/19 (95%)
sp8a	NP_998406.2	C2H2 Zn finger	285..304	CDD:275368	18/18 (100%)
		zf-H2C2_2	296..323	CDD:290200	26/26 (100%)
		C2H2 Zn finger	312..334	CDD:275368	21/21 (100%)
		zf-H2C2_2	326..349	CDD:290200	21/22 (95%)
		zf-C2H2	340..362	CDD:278523	19/21 (90%)
		C2H2 Zn finger	342..362	CDD:275368	18/19 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I5066
eggNOG	1	0.900	-	-		E33208_3BAZW
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136645
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2472
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D295820at33208
OrthoFinder	1	1.000	-	-		FOG0001688
OrthoInspector	1	1.000	-	-		otm24821
orthoMCL	1	0.900	-	-		OOG6_106240
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5217
SonicParanoid	1	1.000	-	-		X2523
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860