Protein Alignment Sp1 and Sp8

DIOPT Version :9

• Sequence 1: NP_001259388.1
• Gene: Sp1 / 31913
• FlyBaseID: FBgn0020378
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001366308.1
• Gene: Sp8 / 320145
• MGIID: 2443471
• Length: 504
• Species: Mus musculus
• Alignment Length: 554
• Identity: 248/554 - (44%)
• Similarity: 296/554 - (53%)
• Gaps: 144/554 - (25%)

  Fly    39 DHPSLRGTPLAMLAAQCNKLSNKSPPP--LAD--AAVGKGFHPWKKSPNSPA-----AGSS---- 90
            :.|.|..||||||||.|||:.:.||.|  |:|  ::.||||||||:|.:|.:     .|||
Mouse     8 EEPRLGSTPLAMLAATCNKIGSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSGSCNVVGSSLSSF 72

  Fly    91 GSSGGGGGGGGSSAGQHSPCAISAA----SSSSSSGSSGGQSSRSLSSS-----ASTMVNITASR 146
            |.||....||.|||...:..|.:||    |.|.|.|.|.|.|:.||:||     |:......:|.
Mouse    73 GVSGASRNGGSSSAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSS 137

  Fly   147 PLAS----------SCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHM 201
            |.|:          |..:.|||..|...|.:.||.||
Mouse   138 PFANDYSVFQAPGVSGGSGGGGGGGGGGSGAHSQDSS---------------------------- 174

  Fly   202 HQGL-LGKVEAGAAAFGGVYSR----HPYDWPFNAVTHK---EAASVN----SGWWDMHSAAGSW 254
            ||.: :.||........|:|.|    |||:..|.. :|.   .||.|.    |.|||:  .|| |
Mouse   175 HQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFKP-SHPGLGAAADVGSAGASSWWDV--GAG-W 235

  Fly   255 LDM-----------------GG--AGMHSTMANYASENY---------SSALSHSLLGSGQHLLQ 291
            :|:                 ||  ..:||.:..|.|: |         |.|.||.|..:||||:
Mouse   236 IDVQNPNGAAALPGSLHPAAGGLQTSLHSPLGGYNSD-YSGLSHSAFSSGASSHLLSPAGQHLM- 298

  Fly   292 DTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYA 356
            |.:|.:|||              |.|.|:||..|.|.::..:|...:..||||.:    |.|||:
Mouse   299 DGFKPVLPG--------------SYPDSAPSPLAGAGSSMLSAGPAAQLGGSPRS----SARRYS 345

  Fly   357 GRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLF 421
            ||||||||||||||||||||..||:|.:|||||||||||||||||||||||||||||||||||||
Mouse   346 GRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLF 410

  Fly   422 CGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGS 486
            |||||||||||||||||||||||||||||||||||||||:||||||:|..   .:..:||.||||
Mouse   411 CGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSGGG---GSAGSGGGKKGS 472

  Fly   487 SESCSDSEEAANQS--------------GESNGL 506
            .   :|||.:|..|              |..|||
Mouse   473 D---TDSEHSAAGSPPCHSPELLQPPEPGHRNGL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	18/18 (100%)
		zf-H2C2_2	401..428	CDD:290200	26/26 (100%)
		C2H2 Zn finger	417..439	CDD:275368	21/21 (100%)
		zf-H2C2_2	431..454	CDD:290200	22/22 (100%)
		zf-C2H2	445..467	CDD:278523	20/21 (95%)
		C2H2 Zn finger	447..467	CDD:275368	18/19 (95%)
Sp8	NP_001366308.1	SP6-9_N	19..375	CDD:425402	144/407 (35%)
		C2H2 Zn finger	379..398	CDD:275368	18/18 (100%)
		zf-H2C2_2	390..417	CDD:404364	26/26 (100%)
		C2H2 Zn finger	406..428	CDD:275368	21/21 (100%)
		zf-H2C2_2	420..443	CDD:404364	22/22 (100%)
		zf-C2H2	434..456	CDD:395048	20/21 (95%)
		C2H2 Zn finger	436..456	CDD:275368	18/19 (95%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3998
eggNOG	1	0.900	-	-		E33208_3BAZW
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2183
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D295820at33208
OrthoFinder	1	1.000	-	-		FOG0001688
OrthoInspector	1	1.000	-	-		otm44150
orthoMCL	1	0.900	-	-		OOG6_106240
Panther	1	1.100	-	-	LDO	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2523
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830