DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and btd

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	197/704 - (27%)
Similarity:	262/704 - (37%)	Gaps:	198/704 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QKPQVNPDHPSLRGTPLAMLAAQCNKLSNKSPPPLADAAVGK--------GFHPWKKSPNSPAAG 88
            |:|| ...|..|  :..|:|:|         ||.|:.::.|.        |..|.|.....|.|.
  Fly    83 QQPQ-QQQHDFL--SAAALLSA---------PPSLSGSSSGSSSGSSPLYGKPPMKLELPYPQAS 135

  Fly    89 SSGSSGGGGGGGGSSAGQHSPCAISAASSSSSSGSSGGQSSRSLSSSASTMVNITASRPLASSCA 153
            |:|::      ..:|:.|.:|   |:||.|.|...|..||..|:|:|.||... |.:.|..::..
  Fly   136 STGTA------SPNSSIQSAP---SSASVSPSIFPSPAQSFASISASPSTPTT-TLAPPTTAAAG 190

  Fly   154 AVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGG 218
            |:.|..|.||.|:|.: |::.|:|.|||...||                         ||||
  Fly   191 ALAGSPTSSSPSSSAA-SAAAAAAAAAAAAADL-------------------------GAAA--- 226

  Fly   219 VYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLL 283
                              .||...||...:|.      :|.|......|.|||:.|.:|
  Fly   227 ------------------VASAAYGWNTAYSG------LGPARSQFPYAQYASDYYGNA------ 261

  Fly   284 GSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPS 348
                                     |||                   :::||..|.|   .....
  Fly   262 -------------------------VGM-------------------SSSAAWFSHQ---ERLYQ 279

  Fly   349 PRSQRRYAG---------------RATCDCPNC-QEAERLGP-AGVHLRKKNIHSCHIPGCGKVY 396
            |.|.:.|.|               ...|.|||| .|...|.| .|...|.:..|.||||||.::|
  Fly   280 PWSSQSYPGFNFDDIAFQTQLQRRSVRCTCPNCTNEMSGLPPIVGPDERGRKQHICHIPGCERLY 344

  Fly   397 GKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLA 461
            ||.||||.|||||||||||:|  |.|||||:||||||||.||||..:.:|||:|:|:|.|||||:
  Fly   345 GKASHLKTHLRWHTGERPFLC--LTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLS 407

  Fly   462 KHVKTH----------NGTANHQANGHNGGLK-----KGSSESCSDSEEAANQSGESNGLGGVGS 511
            ||.|||          ...|..||   ...:|     |.|.:..:...|...:..::..|  |..
  Fly   408 KHKKTHFKDKKSKKVLAAEAKEQA---AAAIKLEKKEKKSGKPLTPPVEFKQEQPDTTPL--VNY 467

  Fly   512 GPQTGGAGGGGGGSSSGN----GAGTLAVSGSVTTGAGAGSGTGSSNSNSNSGG---SSGSVSGS 569
            .|............||.|    .........:.||.:.|.|......|:|:|..   ::.|.|.|
  Fly   468 APYANLYQHSTSAGSSVNPPPPPPPLFQQQMTTTTSSAAASFVEQPWSSSSSRAIQPATTSASSS 532

  Fly   570 VSGSGSHPGTPTSLHAHSANGTSSSLLGGGLHLATPHQMVAAGGSPVMLHQQQQQQQHQQQQQQQ 634
            .|.|.|.|.....    ||.|::||.......||..|....|     |..:.|...::.......
  Fly   533 SSSSASSPAAAVV----SAIGSASSPAASATALAQHHYAALA-----MQSESQLAAEYGLTMSGL 588

  Fly   635 QQQQHQQQQQQQHQQQQQQHQQ-------QQQQHHQQQQQHHHQQFGQQQHPHA 681
            .....|......|.:.:.....       .....:.....|||..:....||||
  Fly   589 ASGASQDSSSSCHMKSEYAASYPADFGAGTASYGYPHPHPHHHNAWAAAYHPHA 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	13/18 (72%)
		zf-H2C2_2	401..428	CDD:290200	21/26 (81%)
		C2H2 Zn finger	417..439	CDD:275368	16/21 (76%)
		zf-H2C2_2	431..454	CDD:290200	14/22 (64%)
		zf-C2H2	445..467	CDD:278523	14/21 (67%)
		C2H2 Zn finger	447..467	CDD:275368	13/19 (68%)
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	13/18 (72%)
		zf-H2C2_2	349..374	CDD:290200	21/26 (81%)
		C2H2 Zn finger	365..385	CDD:275368	16/21 (76%)
		zf-H2C2_2	377..402	CDD:290200	15/24 (63%)
		zf-C2H2	391..413	CDD:278523	14/21 (67%)
		C2H2 Zn finger	393..413	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	67	1.000	Inparanoid score	I1951
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14801
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.990