DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and Sp5

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001100022.1	Gene:	Sp5 / 296510	RGDID:	1308499	Length:	398	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	169/494 - (34%)
Similarity:	204/494 - (41%)	Gaps:	165/494 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PQVNPD---HPSLRGTPLAMLAAQCNKLSN----KSPPPLA---DAAVG---KGFHPWKKSPNSP 85
            |..:||   |     :|||:|||.|:::..    .:|..|.   |.|:|   :.||||  :.:.|
  Rat    21 PSASPDLGKH-----SPLALLAATCSRIGQPGAAAAPDFLQVPYDPALGSPSRLFHPW--TADMP 78

  Fly    86 AAGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSS--------SGSSGGQSSRSLSSSA--STMV 140
            |                    |||.|:.....|..        ..|.|......|:..|  |...
  Rat    79 A--------------------HSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPY 123

  Fly   141 NITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGL 205
            ..:..:.|.||.||:      .:|.|......:..:|:...|...|..|...........:
  Rat   124 EFSPVKMLPSSMAAL------PASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQL---- 178

  Fly   206 LGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDM-HSAAGSWLDMGGAGMHSTMANY 269
                 :.|.|        |.|.|               ||.: .|.||.    |.:|:..|
  Rat   179 -----SPAPA--------PDDLP---------------WWSIPQSGAGP----GSSGVPGT---- 207

  Fly   270 ASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSS--PSAAAAAAATAA 332
                   :||.:..|.                               ||:.  |::||||||.||
  Rat   208 -------SLSSACAGP-------------------------------PHAPRFPASAAAAAAAAA 234

  Fly   333 AAAGGSPQGGS-----------------PSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLR 380
            |...|...|.|                 |...:.|..||      |.|||||.|.  |.......
  Rat   235 ALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRR------CRCPNCQAAG--GAPEAEPG 291

  Fly   381 KKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRF 445
            ||..|.||:|||||||||||||||||||||||||||||||||||.||||||||||||||||||||
  Rat   292 KKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRF 356

  Fly   446 ACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKK 484
            |||.|.||||||||||||||||.   |.:......|:|:
  Rat   357 ACPECGKRFMRSDHLAKHVKTHQ---NKKLKVAEAGVKR 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	18/18 (100%)
		zf-H2C2_2	401..428	CDD:290200	25/26 (96%)
		C2H2 Zn finger	417..439	CDD:275368	20/21 (95%)
		zf-H2C2_2	431..454	CDD:290200	20/22 (91%)
		zf-C2H2	445..467	CDD:278523	19/21 (90%)
		C2H2 Zn finger	447..467	CDD:275368	17/19 (89%)
Sp5	NP_001100022.1	SP1-4_N	31..>47	CDD:425404	7/15 (47%)
		SP5_N	106..297	CDD:412096	60/282 (21%)
		C2H2 Zn finger	301..320	CDD:275368	18/18 (100%)
		COG5048	<311..384	CDD:227381	66/75 (88%)
		C2H2 Zn finger	328..350	CDD:275368	20/21 (95%)
		zf-H2C2_2	342..365	CDD:404364	20/22 (91%)
		C2H2 Zn finger	358..378	CDD:275368	17/19 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010