DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and Sp1

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_036787.2	Gene:	Sp1 / 24790	RGDID:	3738	Length:	786	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	183/584 - (31%)
Similarity:	233/584 - (39%)	Gaps:	167/584 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SPNSPAA--GSSGSSGGGGGGGGSSAGQHSPCAISAASSSS------------------------ 119
            :|:|.|.  .||||...|.....|.....|...:|:.:|||
  Rat   279 TPSSQAGTISSSGSQESGSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFT 343

  Fly   120 SSGSSG----GQSSRSLSS-SASTMVNITASRPLASSCAAVGGGSTGSSSSASGSQSSST----- 174
            ||||||    ||:|:.:.. ..|..:||..::        ..|||...|....|.||..|
  Rat   344 SSGSSGTSSQGQTSQRVGGLQGSDSLNIQQNQ--------TSGGSLQGSQQKEGEQSQQTQQQQI 400

  Fly   175 ---------ASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHP------ 224
                     ..|:.|.....|.....:|..:....:....|..|:..    |.:..|.|
  Rat   401 LIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNS----GPIIIRTPTVGPNG 461

  Fly   225 -YDW---------------------PFNAVTHKEAASVNSGWWDMHSAAGSWLDMG----GAGMH 263
             ..|                     |...|:..:.:|.|:....:.|||.  :..|    .|...
  Rat   462 QVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAAS--IPAGTVTVNAAQL 524

  Fly   264 STMANYASENYSSALSHSLLG-SGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAA 327
            |:|....:.|.|:      || ||..:.|      |||..:.:....|..|..|....|......
  Rat   525 SSMPGLQTINLSA------LGTSGIQVHQ------LPGLPLAIANTPGDHGAQLGLHGPGGDGIH 577

  Fly   328 AATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLG---PAGVHLRKKNIHSCHI 389
            ..||     |..:|.:...|.|::.|| ..|..|.||.|:::|..|   |.     ||..|.|||
  Rat   578 DETA-----GGEEGENSPDPQPQAGRR-TRREACTCPYCKDSEGRGSGDPG-----KKKQHICHI 631

  Fly   390 PGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRF 454
            .||||||||||||:||||||||||||:|||.:||||||||||||||.|||||||:||||.|.|||
  Rat   632 QGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRF 696

  Fly   455 MRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGESNGLG---GVGSGPQTG 516
            ||||||:||:|||..             |||                   |.|   .||:.|...
  Rat   697 MRSDHLSKHIKTHQN-------------KKG-------------------GPGVALSVGTLPLDS 729

  Fly   517 GAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSG------TGSSNSNSNSGGSSGSVSGSVSGSG 574
            |||        ..|:||...|..:||...|...      ...:||..|....:...|.::||:|
  Rat   730 GAG--------SEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNG 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	16/18 (89%)
		zf-H2C2_2	401..428	CDD:290200	22/26 (85%)
		C2H2 Zn finger	417..439	CDD:275368	18/21 (86%)
		zf-H2C2_2	431..454	CDD:290200	18/22 (82%)
		zf-C2H2	445..467	CDD:278523	17/21 (81%)
		C2H2 Zn finger	447..467	CDD:275368	15/19 (79%)
Sp1	NP_036787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94
		Repressor domain. /evidence=ECO:0000250	2..83
		SP1-4_N	55..628	CDD:425404	125/429 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..143
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	147..252
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	262..496		62/294 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..303		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..397		15/79 (19%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P08047	463..471		1/7 (14%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	497..611		48/116 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..600		21/40 (53%)
		VZV IE62-binding. /evidence=ECO:0000250	620..786		65/162 (40%)
		zf-C2H2	627..651	CDD:395048	19/23 (83%)
		C2H2 Zn finger	629..651	CDD:275368	17/21 (81%)
		zf-H2C2_2	643..670	CDD:404364	19/26 (73%)
		C2H2 Zn finger	659..681	CDD:275368	5/21 (24%)
		zf-H2C2_2	673..696	CDD:404364	3/22 (14%)
		zf-C2H2	687..709	CDD:395048	3/24 (13%)
		C2H2 Zn finger	689..709	CDD:275368	3/22 (14%)
		Domain D. /evidence=ECO:0000250	709..786		18/70 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010