DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sp1 and Klf10

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_036015210.1	Gene:	Klf10 / 21847	MGIID:	1101353	Length:	547	Species:	Mus musculus

Alignment Length:	481	Identity:	131/481 - (27%)
Similarity:	187/481 - (38%)	Gaps:	121/481 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SNIATHLQKPQVNP------DHPSLRGTP-LAMLAAQC---------------NKLSNKSP---- 63
            |:...:|:...|.|      |...|.||| |..:.|.|               :.|:..:|
Mouse   121 SHFKKYLENRPVTPVSDTSEDDSLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTASAPSTGH 185

  Fly    64 -PPLADAAVGKGFHPWKKSPNSPAAG----SSGSSGGGGGGGGSSAGQHSPCAISAASSSSSSGS 123
             ...:|||...|..|:|:...:|.|.    .:.::........:....|..|.:.|||..:...:
Mouse   186 FKSFSDAAKPPGATPFKEEEKNPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDN 250

  Fly   124 SGGQSSRSLSSSASTMVNITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYF 188
            |..:  |:..:..:|..||        .||||   |...|.....:.|.....|.||.|  |...
Mouse   251 SFRR--RTHGNVEATRKNI--------PCAAV---SPNRSKPEPSTVSDGDEKAGAALY--DFAV 300

  Fly   189 PNTST-----SNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMH 248
            |::.|     ....:..:.:.:|  |.:...:.|||    |   |...:........|:
Mouse   301 PSSETVICRSQPAPSSPVQKSVL--VSSPTVSTGGV----P---PLPVICQMVPLPANN------ 350

  Fly   249 SAAGSWLDMGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGG 313
                        .:.||:......:...|:...:|..|..:.:.|...::|...|
Mouse   351 ------------SLVSTVVPSTPPSQPPAVCSPVLFMGTQVPEGTVVFVVPQPVV---------- 393

  Fly   314 FSLPHSSPSAAAAAAATAAAAAGGSPQGG--SPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAG 376
                 .||.....           ||.|.  ||..|:|...              ..|.|:.|.
Mouse   394 -----QSPRPPVV-----------SPSGTRLSPIAPAPGFS--------------PSAARVTPQ- 427

  Fly   377 VHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTG 441
            :...:...|.|..|||||.|.|:||||||:|.||||:||.|:|..|.:||.|||||.||.|||||
Mouse   428 IDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTG 492

  Fly   442 EKRFACPVCNKRFMRSDHLAKHVKTH 467
            ||:||||:|::||||||||.||.:.|
Mouse   493 EKKFACPMCDRRFMRSDHLTKHARRH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	14/18 (78%)
		zf-H2C2_2	401..428	CDD:290200	17/26 (65%)
		C2H2 Zn finger	417..439	CDD:275368	13/21 (62%)
		zf-H2C2_2	431..454	CDD:290200	16/22 (73%)
		zf-C2H2	445..467	CDD:278523	15/21 (71%)
		C2H2 Zn finger	447..467	CDD:275368	13/19 (68%)
Klf10	XP_036015210.1	KLF10_N	101..436	CDD:409241	74/397 (19%)
		COG5048	441..>491	CDD:227381	34/49 (69%)
		C2H2 Zn finger	441..460	CDD:275368	14/18 (78%)
		C2H2 Zn finger	468..490	CDD:275368	13/21 (62%)
		zf-C2H2	496..518	CDD:395048	15/21 (71%)
		C2H2 Zn finger	498..518	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910