DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sp1 and Sp1

DIOPT Version :9

Sequence 1:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_038700.2	Gene:	Sp1 / 20683	MGIID:	98372	Length:	781	Species:	Mus musculus

Alignment Length:	556	Identity:	179/556 - (32%)
Similarity:	236/556 - (42%)	Gaps:	114/556 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SPNSPAAGSSGSSGGGGGGGGSSAGQHSPCAISAAS--SSSSSGSSGGQSSRSLSSSAST----M 139
            :|:|.|    |:....|....||....|..|||:||  ||.:|.||...::.|.|::.:|    :
Mouse   277 TPSSQA----GTISSSGSQESSSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGI 337

  Fly   140 VNITASRPLASSCAA-----VG----------------GGSTGSSSSASGSQSSST--------- 174
            :|.|:|....:|...     ||                |||...|....|.||..|
Mouse   338 MNFTSSGSSGTSSQGQTPQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQP 402

  Fly   175 -----ASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTH 234
                 ..|:.|.....|.....:|..:....:....|..|:..    |.:..|.|...|...|:.
Mouse   403 QLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNS----GPIIIRTPTVGPNGQVSW 463

  Fly   235 KEAASVNSGWWDMHSAAGSWLDMGGAGMHST-MANYASENYSSALSHSLLGSGQHLLQDTYKSML 298
            :.....|....:..:...:...|.|..:..| .:|......:||.|   :.:|...:.....|.:
Mouse   464 QTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAAS---IPAGTVTVNAAQLSSM 525

  Fly   299 PG-QGVGVGVGVGMGGFSLPHSSPSAAAAAAATAA------------------AAAGGSPQGGSP 344
            || |.:.:. .:|..|..: |..|....|.|.|..                  ..|||  :|.:.
Mouse   526 PGLQTINLS-ALGTSGIQV-HQLPGLPLAIANTPGDHGTQLGLHGSGGDGIHDETAGG--EGENS 586

  Fly   345 STPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWH 409
            |...|::.|| ..|..|.||.|:::|  |.|.....||..|.|||.||||||||||||:||||||
Mouse   587 SDLQPQAGRR-TRREACTCPYCKDSE--GRASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWH 648

  Fly   410 TGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQ 474
            ||||||:|||.:||||||||||||||.|||||||:||||.|.|||||||||:||:|||..
Mouse   649 TGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQN----- 708

  Fly   475 ANGHNGGLKKGSSESCSDSEEAANQSGESNGLGGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGS 539
                    |||               |....| .||:.|...|||..|..:.|     .|..:..
Mouse   709 --------KKG---------------GPGVAL-SVGTLPLDSGAGSEGTATPS-----ALITTNM 744

  Fly   540 VTTGAGAGSGTGS-SNSNSNSGGSSGSVSGSVSGSG 574
            |...|....|... :||..|....:...|.::||:|
Mouse   745 VAMEAICPEGIARLANSGINVMQVTELQSINISGNG 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	16/18 (89%)
		zf-H2C2_2	401..428	CDD:290200	22/26 (85%)
		C2H2 Zn finger	417..439	CDD:275368	18/21 (86%)
		zf-H2C2_2	431..454	CDD:290200	18/22 (82%)
		zf-C2H2	445..467	CDD:278523	17/21 (81%)
		C2H2 Zn finger	447..467	CDD:275368	15/19 (79%)
Sp1	NP_038700.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95
		Repressor domain. /evidence=ECO:0000250	2..84
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	145..250
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	260..494		56/258 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..300		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..395		19/103 (18%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P08047	461..469		2/8 (25%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	495..608		51/131 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..595		16/31 (52%)
		VZV IE62-binding. /evidence=ECO:0000250	617..781		64/155 (41%)
		C2H2 Zn finger	626..648	CDD:275368	18/21 (86%)
		COG5048	<639..710	CDD:227381	27/70 (39%)
		zf-H2C2_2	640..667	CDD:290200	19/26 (73%)
		C2H2 Zn finger	656..678	CDD:275368	6/21 (29%)
		zf-H2C2_2	670..693	CDD:290200	3/22 (14%)
		zf-C2H2	684..706	CDD:278523	2/21 (10%)
		C2H2 Zn finger	686..706	CDD:275368	2/19 (11%)
		Domain D. /evidence=ECO:0000250	706..781		18/66 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010