Protein Alignment Sp1 and klf-1

DIOPT Version :10

• Sequence 1: NP_001259388.1
• Gene: Sp1 / 31913
• FlyBaseID: FBgn0020378
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_497632.1
• Gene: klf-1 / 175404
• WormBaseID: WBGene00018990
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 552
• Identity: 139/552 - (25%)
• Similarity: 199/552 - (36%)
• Gaps: 162/552 - (29%)

  Fly    22 MNISNI-ATHLQKPQVN-PDHPSLRGTPLAMLAAQCNKLSNKSPPPLADAAVGKGFHPWKKSPNS 84
            |..|:| ||..::|.:: |:.|||...|||.                ||.:|..          |
 Worm     1 MTSSSINATSSREPLIHIPNKPSLSIDPLAR----------------ADRSVHL----------S 39

  Fly    85 PAAGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSSSGSSGGQSSRSLSSSASTMVNITAS---R 146
            |:....|.|........:....|     .|..|.:..|....:|.|.||.|.|....:.|:   |
 Worm    40 PSFFQPGLSSISSENDDAEQRIH-----EATRSFNQFGHQFYESIRELSESTSAYERLKANALRR 99

  Fly   147 PLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGG------DLYFPNTSTSNMDNHHMHQ-- 203
            .|.::.....|.:| ||||:|..:..|..||.|.....      .|:.|.||.    |..:.|
 Worm   100 KLENTFGNDSGAAT-SSSSSSVFERQSDFSAFAPYKNSHFDSTQSLFQPTTSF----NDRLEQIK 159

  Fly   204 -GLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSW--------LDMGG 259
             ..:.:.:...::|.|          ||..|    .::.:.:..|.....::        ||...
 Worm   160 SDFIAEHQKSMSSFSG----------FNTPT----TALGAAFQGMQVKKSAFAPVLLRENLDTRR 210

  Fly   260 AGMH--STMAN-----------------------YASENYSSALSHSLLGSGQHLLQDTYKSM-- 297
            .|.|  |.:.|                       :::.|:..|.|.|  |...|  || ::|:
 Worm   211 PGGHLISDILNRDPLPQSRNLNLNMARNVPIRLIHSTSNFDIASSSS--GDSGH--QD-HESIVV 270

  Fly   298 ---------------------LPGQGVGVGVGVGMGGFSLPHSSPSAAAAAA------------- 328
                                 |..:.:.|.|........||.|..|:..:..
 Worm   271 EDADMDSPTSPCVKRSAMNFDLRDEPLTVNVESVSSTSDLPSSVSSSVNSFVYQNFDPLEFKRKI 335

  Fly   329 --ATAAAAAGGSPQGGSPSTP---------------------SPRSQRRYAGRATCDCPNCQEAE 370
              .||:|.....|.......|                     :..|||.:...:..| .||:.:.
 Worm   336 DELTASACLAVMPDANGQVDPMAIKTQLDAIKKQMEEHQTHMAEASQRLHVDSSLED-SNCEPSP 399

  Fly   371 RLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRH 435
            ...........|.:|.|..|.|||||.|:||||||.|.||||:|:.|:|..|..||.|||||.||
 Worm   400 SSSYDASEPSVKRLHHCTHPNCGKVYTKSSHLKAHFRTHTGEKPYECSWDGCDWRFARSDELTRH 464

  Fly   436 LRTHTGEKRFACPVCNKRFMRSDHLAKHVKTH 467
            .|.|||::.|.|..|::.|.|||||:.|:|.|
 Worm   465 YRKHTGDRPFKCSQCSRAFSRSDHLSLHMKRH 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	SP6-9-like_N	50..386	CDD:411694	77/439 (18%)
		C2H2 Zn finger	390..409	CDD:275368	14/18 (78%)
		zf-H2C2_2	401..428	CDD:463886	16/26 (62%)
		C2H2 Zn finger	417..439	CDD:275368	13/21 (62%)
		zf-H2C2_2	431..454	CDD:463886	11/22 (50%)
		zf-C2H2	445..467	CDD:395048	11/21 (52%)
		C2H2 Zn finger	447..467	CDD:275368	10/19 (53%)
klf-1	NP_497632.1	C2H2 Zn finger	419..438	CDD:275368	14/18 (78%)
		zf-H2C2_2	430..457	CDD:463886	16/26 (62%)
		C2H2 Zn finger	446..468	CDD:275368	13/21 (62%)
		zf-H2C2_2	460..485	CDD:463886	12/24 (50%)
		C2H2 Zn finger	476..496	CDD:275368	10/19 (53%)