DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sp1 and klf2a

DIOPT Version :10

Sequence 1:NP_001259388.1 Gene:Sp1 / 31913 FlyBaseID:FBgn0020378 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_571931.2 Gene:klf2a / 117508 ZFINID:ZDB-GENE-011109-1 Length:380 Species:Danio rerio


Alignment Length:314 Identity:94/314 - (29%)
Similarity:122/314 - (38%) Gaps:98/314 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 SAAGSWLDMGGAGMHSTMANYASEN-------------------YSSALSHSLLGS--------- 285
            :.|||  |..|.||........|.|                   |:::|...||.|         
Zfish    69 NTAGS--DNLGLGMAGDYRMQESRNMYNPTTYSVPEINPSPPPPYTTSLMAELLQSDIDTYCQPS 131

  Fly   286 --GQHLLQ------------------DTY---KSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAA 327
              |:.|::                  |:|   :.|:| :....|.|..|..:..|..:.|...|.
Zfish   132 LQGRFLVRPAFPTQDISECIKVEPCMDSYGPVRGMVP-KVKQEGNGACMRSYEQPRLANSPQGAG 195

  Fly   328 AATA--------------------AAAAGGSPQG--GSPSTPSPRSQRRYAGR---ATCD----C 363
            :.|.                    |.....|.||  |.|....|:.|..|...   :.||    .
Zfish   196 SMTPPQSPAELINTDCQSHSQMCHALTFSQSYQGNTGFPHAAPPQMQLPYQSTHHFSMCDDGLAM 260

  Fly   364 PNCQEAERLGPAGVHL--------------RKKN-IHSCHIPGCGKVYGKTSHLKAHLRWHTGER 413
            ||..:...|.|....|              ||:. .|:|...||||.|.|:||||||.|.||||:
Zfish   261 PNANQRVLLTPPSSPLELDAKPKRGRRTWPRKRTATHTCTFSGCGKTYTKSSHLKAHHRTHTGEK 325

  Fly   414 PFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTH 467
            |:.|:|..||.:|.|||||.||.|.|||.:.|.|.:|.:.|.||||||.|:|.|
Zfish   326 PYHCSWEGCGWKFARSDELTRHFRKHTGHRPFQCHLCERAFSRSDHLALHMKRH 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sp1NP_001259388.1 SP6-9-like_N 50..386 CDD:411694 45/231 (19%)
C2H2 Zn finger 390..409 CDD:275368 13/18 (72%)
zf-H2C2_2 401..428 CDD:463886 16/26 (62%)
C2H2 Zn finger 417..439 CDD:275368 13/21 (62%)
zf-H2C2_2 431..454 CDD:463886 11/22 (50%)
zf-C2H2 445..467 CDD:395048 12/21 (57%)
C2H2 Zn finger 447..467 CDD:275368 11/19 (58%)
klf2aNP_571931.2 KLF2_N 4..297 CDD:409229 45/230 (20%)
C2H2 Zn finger 302..321 CDD:275368 13/18 (72%)
COG5048 304..>352 CDD:227381 30/47 (64%)
C2H2 Zn finger 329..351 CDD:275368 13/21 (62%)
zf-H2C2_2 343..368 CDD:463886 12/24 (50%)
C2H2 Zn finger 359..379 CDD:275368 11/19 (58%)

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