DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sp1 and Klf3

DIOPT Version :10

Sequence 1:NP_001259388.1 Gene:Sp1 / 31913 FlyBaseID:FBgn0020378 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_001099212.1 Gene:Klf3 / 114845 RGDID:1593290 Length:344 Species:Rattus norvegicus


Alignment Length:354 Identity:95/354 - (26%)
Similarity:122/354 - (34%) Gaps:129/354 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 GSSSSASGSQSS-------------------------STASAVAAAYGGDLYFPNTSTSNMDNHH 200
            ||..||:||.||                         |..|.....:|..|..|....:.:..|.
  Rat    70 GSPPSAAGSPSSLKFPSHRRASPGLSMPSSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALTRHG 134

  Fly   201 MHQ-GLLGKVE---AGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMG--- 258
            :.. |:|..::   .....|  :|:.| ...|......:|..:.|||             |.   
  Rat   135 IRSPGILPVIQPVVVQPVPF--MYTSH-LQQPLMVSLSEEMDNSNSG-------------MPVPV 183

  Fly   259 ---------------GAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVG 308
                           ..|:.....:|..|..|..|.:| :...|.|||:.:.|::          
  Rat   184 IESYEKPILQKKIKIEPGIEPQRTDYYPEEMSPPLMNS-VSPPQALLQENHPSVI---------- 237

  Fly   309 VGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLG 373
            |..|...||..||...                                                 
  Rat   238 VQPGKRPLPVESPDTQ------------------------------------------------- 253

  Fly   374 PAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRT 438
                  ||:.||.|...||.|||.|:||||||.|.||||:|:.|.|..|..:|.|||||.||.|.
  Rat   254 ------RKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRK 312

  Fly   439 HTGEKRFACPVCNKRFMRSDHLAKHVKTH 467
            |||.|.|.||.|::.|.||||||.|.|.|
  Rat   313 HTGIKPFQCPDCDRSFSRSDHLALHRKRH 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sp1NP_001259388.1 SP6-9-like_N 50..386 CDD:411694 45/271 (17%)
C2H2 Zn finger 390..409 CDD:275368 13/18 (72%)
zf-H2C2_2 401..428 CDD:463886 15/26 (58%)
C2H2 Zn finger 417..439 CDD:275368 12/21 (57%)
zf-H2C2_2 431..454 CDD:463886 13/22 (59%)
zf-C2H2 445..467 CDD:395048 13/21 (62%)
C2H2 Zn finger 447..467 CDD:275368 12/19 (63%)
Klf3NP_001099212.1 KLF3_N 49..259 CDD:410554 44/270 (16%)
zf-C2H2 259..283 CDD:395048 15/23 (65%)
C2H2 Zn finger 261..283 CDD:275368 14/21 (67%)
C2H2 Zn finger 291..313 CDD:275368 12/21 (57%)
zf-H2C2_2 305..330 CDD:463886 14/24 (58%)
C2H2 Zn finger 321..341 CDD:275368 12/19 (63%)

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