DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sp1 and KLF18

DIOPT Version :10

Sequence 1:NP_001259388.1 Gene:Sp1 / 31913 FlyBaseID:FBgn0020378 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_001345367.1 Gene:KLF18 / 105378952 HGNCID:51793 Length:1052 Species:Homo sapiens


Alignment Length:424 Identity:107/424 - (25%)
Similarity:167/424 - (39%) Gaps:93/424 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 SSAGQHSPCAISAASSSSSSGSSGGQSSRSLSSSASTMVNITASRPLASSCA----------AVG 156
            :|.|..:.|.....:|:.:....|||.:.|.|:........|.|....:.|.          |:.
Human   660 TSTGNQALCGEQMTTSTGNQALYGGQMTTSTSNQTLCGEQTTTSTSNQTLCGEQVTTSTGNQALY 724

  Fly   157 GG----STGSSS-------SASGSQS-----SSTASAVAAAYGGDLYFPNTSTSN-------MDN 198
            ||    |||:.:       :::|:|:     .:|::...|.|||.:   .|||||       |..
Human   725 GGQMMTSTGNQTLYWGQMMTSTGNQNLCGEQMTTSTGNQALYGGQM---TTSTSNQTLCGEQMTT 786

  Fly   199 HHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSG-----WWDMHSAAGSWLDMG 258
            ...:|.|.|:....:.....:|.........|.....|..:.::.     ...:.::.|:....|
Human   787 PTSNQTLCGEQVTTSTGNQALYRGQITTSTSNQTLCGEQMTTSTSNQTLCGEQVTTSTGNQALYG 851

  Fly   259 GAGMHSTMAN---YASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGM--------- 311
            |..|.|| .|   |..:|.:|..:.:|.| ||.......:::...|.:.:.|| .|         
Human   852 GQMMTST-GNQNLYGGQNMTSTDNQALYG-GQMATYSGNQTLYGDQMLTLQVG-NMTTLTDDHSL 913

  Fly   312 -GGFSLPH---SSPSAAAAAAATAAAAAGGSPQGGSPST---PSPRSQRRYAGRATCDCPNCQEA 369
             ||:.:.|   |.|.......:::....|..|:..:.|.   .:|...|.|.             
Human   914 YGGYMMSHQFSSLPYPGFLCFSSSHLIQGQLPKQKTQSCQFWKNPEVSRPYV------------- 965

  Fly   370 ERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQR 434
                             |....|...|.|..||:.|:|.||||:|:||:...|..:|.|||||.|
Human   966 -----------------CTYEDCKMSYSKACHLRTHMRKHTGEKPYVCDVEGCTWKFARSDELNR 1013

  Fly   435 HLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHN 468
            |.:.||||:.:.|.:|:|.|.|||||.:|.|.||
Human  1014 HKKRHTGERPYLCSICSKNFARSDHLKQHAKVHN 1047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sp1NP_001259388.1 SP6-9-like_N 50..386 CDD:411694 66/340 (19%)
C2H2 Zn finger 390..409 CDD:275368 7/18 (39%)
zf-H2C2_2 401..428 CDD:463886 13/26 (50%)
C2H2 Zn finger 417..439 CDD:275368 10/21 (48%)
zf-H2C2_2 431..454 CDD:463886 11/22 (50%)
zf-C2H2 445..467 CDD:395048 11/21 (52%)
C2H2 Zn finger 447..467 CDD:275368 11/19 (58%)
KLF18NP_001345367.1 KLF18_N 100..384 CDD:410566
KLF18_N 272..580 CDD:410566
KLF18_N 650..960 CDD:410566 64/305 (21%)
C2H2 Zn finger 969..988 CDD:275368 7/18 (39%)
zf-H2C2_2 980..1007 CDD:463886 13/26 (50%)
C2H2 Zn finger 996..1018 CDD:275368 10/21 (48%)
zf-H2C2_2 1010..1035 CDD:463886 12/24 (50%)
C2H2 Zn finger 1026..1046 CDD:275368 11/19 (58%)
Blue background indicates that the domain is not in the aligned region.

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