Protein Alignment Sp1 and sp8

DIOPT Version :10

• Sequence 1: NP_001259388.1
• Gene: Sp1 / 31913
• FlyBaseID: FBgn0020378
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_001278991.1
• Gene: sp8 / 100492429
• XenbaseID: XB-GENE-1216189
• Length: 520
• Species: Xenopus tropicalis
• Alignment Length: 634
• Identity: 253/634 - (39%)
• Similarity: 306/634 - (48%)
• Gaps: 205/634 - (32%)

  Fly    39 DHPSLRGTPLAMLAAQCNKLSNKSPPP--LAD--AAVGKGFHPWKKSPNSP-----AAGS-SGSS 93
            :.|.|..||||||||.|||:.:.||.|  |:|  |:.||||||||:|.::.     |:|| ||.|
 Frog     8 EEPRLGSTPLAMLAATCNKIGSPSPSPSSLSDSSASFGKGFHPWKRSSSTSSSCTLASGSLSGFS 72

  Fly    94 GGG---GGGGGSSAGQHSPCAISAA------SSSSSSGSSGGQSSRSLSSSASTMVNITASRPLA 149
            .||   ||.|.|||...:..|.:||      |.|.|.|.|.|.|:.||:|.             .
 Frog    73 VGGSSRGGNGSSSAAAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSG-------------V 124

  Fly   150 SSCAAVGGGSTGSSSSAS-------------GSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHM 201
            |.....||||:||.|:||             |||.::.|:|.|||          :.:...:||
 Frog   125 SGGGGGGGGSSGSVSAASPFANEYSVFPVSGGSQEAAAAAAAAAA----------AAAAAASHH- 178

  Fly   202 HQGLLGKVEAGAAAFGGVYSR----HPYDWPFNAVTHKE----AASVNSGWWDMHSAAGSWLDM- 257
            ....|.||.|.......:|.|    |||:..|......|    ||...|.||::  .|| |:|:
 Frog   179 QPVFLSKVHASVDGLQSIYPRVGMAHPYESWFKPSHPGEVSAAAAGGASSWWEV--GAG-WIDVQ 240

  Fly   258 -GGAG-----------MHSTMANYASENYSSAL-----------------------------SHS 281
             .|||           :||.:..|.::..::.|                             ||.
 Frog   241 SPGAGAALHPGALQGSLHSPLGGYGTDYSAAGLGHFSAGGGGGAGSGGGAAGAGNGGGGGPGSHL 305

  Fly   282 LLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPST 346
            |...|||:: |.:|.:           :|.|.:..|.|||.:|.:..|..      .|.||||.:
 Frog   306 LSSGGQHIM-DGFKPV-----------IGPGSYPDPSSSPLSAGSMLAPT------GPLGGSPRS 352

  Fly   347 PSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTG 411
                |.|||:||||||||||||||||||||..||:|.:|||||||||||||||||||||||||||
 Frog   353 ----SARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTG 413

  Fly   412 ERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQAN 476
            |||||||||||||||||||||||||||||||||||||||||||||||||:||||||:
 Frog   414 ERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHS-------- 470

  Fly   477 GHNGGLKKGSSESCSDSEEAANQSGESNGLGGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVT 541
                                                  .||||||.|                 :
 Frog   471 --------------------------------------AGGAGGGAG-----------------S 480

  Fly   542 TGAGAGSGTGSSNSNSNSGGSSGSVSGSVSGSGSHPGTPTSLHAHSANG 590
            ||.|:||..||...:.:|..:|....           :|..||....||
 Frog   481 TGPGSGSKKGSDTDSEHSPSTSPPCH-----------SPDLLHPPDRNG 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sp1	NP_001259388.1	SP6-9-like_N	50..386	CDD:411694	144/417 (35%)
		C2H2 Zn finger	390..409	CDD:275368	18/18 (100%)
		zf-H2C2_2	401..428	CDD:463886	26/26 (100%)
		C2H2 Zn finger	417..439	CDD:275368	21/21 (100%)
		zf-H2C2_2	431..454	CDD:463886	22/22 (100%)
		zf-C2H2	445..467	CDD:395048	20/21 (95%)
		C2H2 Zn finger	447..467	CDD:275368	18/19 (95%)
sp8	NP_001278991.1	SP6-9_N	19..388	CDD:425402	144/417 (35%)
		C2H2 Zn finger	392..411	CDD:275368	18/18 (100%)
		zf-H2C2_2	403..430	CDD:463886	26/26 (100%)
		C2H2 Zn finger	419..441	CDD:275368	21/21 (100%)
		zf-H2C2_2	433..456	CDD:463886	22/22 (100%)
		zf-C2H2	447..469	CDD:395048	20/21 (95%)
		C2H2 Zn finger	449..469	CDD:275368	18/19 (95%)